ArticleThe European journal of neuroscience2011
Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Alcohol Approach Bias Is Associated With Both Behavioral and Neural Pavlovian-to-Instrumental Transfer Effects in Alcohol-Dependent Patients.Biological psychiatry global open science · 2023Article
- Prefrontal cortex neurons in adult rats exposed to early life stress fail to appropriately signal the consequences of motivated actions.Physiology & behavior · 2023Article
- Computational Mechanisms of Addiction and Anxiety: A Developmental Perspective.Biological psychiatry · 2023Review
- Flexible control of Pavlovian-instrumental transfer based on expected reward value.Journal of experimental psychology. Animal learning and cognition · 2023Article
- The distinct role of orbitofrontal and medial prefrontal cortex in encoding impulsive choices in an animal model of attention deficit hyperactivity disorder.Frontiers in behavioral neuroscience · 2022Article
- Association of theJournal of psychopharmacology (Oxford, England) · 2021Article
- Reward-predictive cues elicit excessive reward seeking in adolescent rats.Developmental cognitive neuroscience · 2020Article
- Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task.The European journal of neuroscience · 2020Article
- Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2019Article
- Not worth the wait: cocaine alters reward processing in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Article
- Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Repeated cocaine exposure dysregulates cognitive control over cue-evoked reward-seeking behavior during Pavlovian-to-instrumental transfer.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Strong seduction: impulsivity and the impact of contextual cues on instrumental behavior in alcohol dependence.Translational psychiatry · 2017Article
- Pavlovian-to-Instrumental Transfer of Nicotine and Food Cues in Deprived Cigarette Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum.The European journal of neuroscience · 2017Article
- Nucleus Accumbens Acetylcholine Receptors Modulate Dopamine and Motivation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
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3 authors at 1 institution in 1 country.
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Abstract
During Pavlovian-to-instrumental transfer (PIT), learned Pavlovian cues significantly modulate ongoing instrumental actions. This phenomenon is suggested as a mechanism under which conditioned stimuli may lead to relapse in addicted populations. Following discriminative Pavlovian learning and instrumental conditioning with sucrose, one group of rats (naive) underwent electrophysiological recordings in the nucleus accumbens core and shell during a single PIT session. Other groups, following Pavlovian and instrumental conditioning, were subsequently trained to self-administer cocaine with nosepoke responses, or received yoked saline infusions and nosepoked for water rewards, and then performed PIT while electrophysiological recordings were taken in the nucleus accumbens. Behaviorally, although both naive and saline-treated groups showed increases in lever pressing during the conditioned stimulus cue, this effect was significantly enhanced in the cocaine-treated group. Neurons in the core and shell tracked these behavioral changes. In control animals, core neurons were significantly more likely to encode general information about cues, rewards and responses than those in the shell, and positively correlated with behavioral PIT performance, whereas PIT-specific encoding in the shell, but not core, tracked PIT performance. In contrast, following cocaine exposure, there was a significant increase in neural encoding of all task-relevant events that was selective to the shell. Given that cocaine exposure enhanced both behavior and shell-specific task encoding, these findings suggest that, whereas the core is important for acquiring the information about cues and response contingencies, the shell is important for using this information to guide and modulate behavior and is specifically affected following a history of cocaine self-administration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.