ArticleThe Journal of parasitology2011
Identification of a sporozoite-specific antigen from Toxoplasma gondii.
Article in The Journal of parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 145 citations in OpenAlex.
- Prevalence of porcine toxoplasmosis using ERP-iELISA in Hubei Province.Parasitology research · 2025Article
- Isolation, genotyping and phenotypingFood and waterborne parasitology · 2025Review
- Development and optimization of an ELISA method to detect Toxoplasma gondii oocyst infection in cats.Parasitology research · 2025Article
- Highlights ofParasitology · 2025Article
- Establishment of an ELISA for detecting oocyst-derivedFrontiers in veterinary science · 2025Article
- Evaluating the significance of Toxoplasma gondii sporozoite antibodies in cats: a pilot study.Parasites & vectors · 2024Article
- In silico study to explore the mechanism of Toxoplasma-induced inflammation and target therapy based on sero and salivary Toxoplasma.Scientific reports · 2024Article
- Spread ofFood and waterborne parasitology · 2023Article
- Limited value of current and newFrontiers in parasitology · 2023Article
- Identification of broadly-conserved parasitic nematode proteins that activate immunity.Frontiers in parasitology · 2023Article
- Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains.Foods (Basel, Switzerland) · 2022Review
- Mining the Proteome ofAnimals : an open access journal from MDPI · 2022Review
- Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.Current pediatrics reports · 2022Review
- Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".Current pediatrics reports · 2022Review
- New Avenues to DesignFrontiers in immunology · 2022Article
- Identification of Oocyst-DrivenMicroorganisms · 2021Review
- Spatial distribution of anti-Toxoplasma gondii antibody-positive wild boars in Gifu Prefecture, Japan.Scientific reports · 2021Article
- Article
- Bilateral ocular toxoplasmosis in a returning traveller: age and route of infection as potential risk factors.BMJ case reports · 2021Article
- Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
Reduction of risk for human and food animal infection with Toxoplasma gondii is hampered by the lack of epidemiological data documenting the predominant routes of infection (oocyst vs. tissue cyst consumption) in horizontally transmitted toxoplasmosis. Existing serological assays can determine previous exposure to the parasite, but not the route of infection. We have used difference gel electrophoresis, in combination with tandem mass spectroscopy and Western blot, to identify a sporozoite-specific protein (T. gondii embryogenesis-related protein [TgERP]), which elicited antibody and differentiated oocyst- versus tissue cyst-induced infection in pigs and mice. The recombinant protein was selected from a cDNA library constructed from T. gondii sporozoites; this protein was used in Western blots and probed with sera from T. gondii -infected humans. Serum antibody to TgERP was detected in humans within 6-8 mo of initial oocyst-acquired infection. Of 163 individuals in the acute stage of infection (anti- T. gondii IgM detected in sera, or < 30 in the IgG avidity test), 103 (63.2%) had detectable antibodies that reacted with TgERP. Of 176 individuals with unknown infection route and in the chronic stage of infection (no anti- T. gondii IgM detected in sera, or > 30 in the IgG avidity test), antibody to TgERP was detected in 31 (17.6%). None of the 132 uninfected individuals tested had detectable antibody to TgERP. These data suggest that TgERP may be useful in detecting exposure to sporozoites in early T. gondii infection and implicates oocysts as the agent of infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.