ArticleThe Journal of parasitology2011
Fasciola hepatica and Schistosoma mansoni: identification of common proteins by comparative proteomic analysis.
Article in The Journal of parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Moonlighting on the Fasciola hepatica tegument: Enolase, a glycolytic enzyme, interacts with the extracellular matrix and fibrinolytic system of the host.PLoS neglected tropical diseases · 2024Article
- Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin.The Korean journal of parasitology · 2022Article
- Pathogenicity and virulence of the liver flukesVirulence · 2021Article
- Modulation of the Functions of Goat Peripheral Blood Mononuclear Cells byPathogens (Basel, Switzerland) · 2020Article
- Proteomics and bioinformatics analysis of Fasciola hepatica somatic proteome in different growth phases.Parasitology research · 2020Article
- The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.Molecules (Basel, Switzerland) · 2017Review
- Proteomic analysis of bleached and unbleached Acropora palmata, a threatened coral species of the Caribbean.Marine pollution bulletin · 2016Article
- Significance of a common 65 kDa antigen in the experimental fasciolosis and toxoplasmosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Transcriptional analysis identifies key genes involved in metabolism, fibrosis/tissue repair and the immune response against Fasciola hepatica in sheep liver.Parasites & vectors · 2015Article
- Serological screening of the Schistosoma mansoni adult worm proteome.PLoS neglected tropical diseases · 2014Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It is not unusual to find common molecules among parasites of different species, genera, or phyla. When those molecules are antigenic, they may be used for developing drugs or vaccines that simultaneously target different species or genera of parasite. In the present study, we used a proteomic-based approach to identify proteins that are common to adult Fasciola hepatica and Schistosoma mansoni. Whole-worm extracts from each parasite were separated by 2-dimensional electrophoresis (2-DE), and digital images of both proteomes were superimposed using imaging software to identify proteins with identical isoelectric points and molecular weights. Protein identities were determined by mass spectrometry. Imaging and immunoblot analyses identified 28 immunoreactive proteins that are common to both parasites. Among these molecules are antioxidant proteins (thioredoxin and glutathione-S-transferase), glycolytic enzymes (glyceraldehyde 6-phosphate dehydrogenase and enolase), proteolytic enzymes (cathepsin-L and -D), inhibitors (Kunitz-type, Stefin-1), proteins with chaperone activity (heat shock protein 70 and fatty acid-binding protein), and structural proteins (calcium-binding protein, actin, and myosin). Some of the identified proteins could be used to develop drugs and vaccines against fascioliasis and schistosomiasis.
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What OpenQuestion holds
Registered trials
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