ArticleNano letters2011
Tuning physical properties of nanocomplexes through microfluidics-assisted confinement.
Article in Nano letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Tuning DLVO Interactions Alters Polymer-Mediated pDNA Delivery in a Cell Type-Dependent Manner.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Article
- Tuning Properties of Polyelectrolyte-Surfactant Associates in Two-Phase Microfluidic Flows.Polymers · 2022Article
- Activation and Switching of Supramolecular Chemical Signals in Multi-Output Microfluidic Devices.Micromachines · 2022Article
- On-Chip Control over Polyelectrolyte-Surfactant Complexation in Nonequilibrium Microfluidic Confinement.Polymers · 2022Article
- Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.Gene therapy · 2022Article
- Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends.Biosensors · 2021Review
- Heat-shrinking DNA nanoparticles for in vivo gene delivery.Gene therapy · 2020Article
- Nanofibrous Scaffolds Containing Hydroxyapatite and Microfluidic-Prepared Polyamidoamin/BMP-2 Plasmid Dendriplexes for Bone Tissue Engineering Applications.International journal of nanomedicine · 2020Article
- Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.Scientific reports · 2018Article
- Continuous Production of Discrete Plasmid DNA-Polycation Nanoparticles Using Flash Nanocomplexation.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?Regenerative biomaterials · 2016Review
- Challenges and Opportunities in Drug Delivery for Wound Healing.Advances in wound care · 2016Review
- Messenger RNA (mRNA) nanoparticle tumour vaccination.Nanoscale · 2014Review
- Article
- Article
- Microfluidic preparation of polymer-nucleic acid nanocomplexes improves nonviral gene transfer.Scientific reports · 2013Article
- Microfluidics-assisted in vitro drug screening and carrier production.Advanced drug delivery reviews · 2013Review
- Microfluidic Assembly of Cationic-β-Cyclodextrin:Hyaluronic Acid-Adamantane Host:Guest pDNA Nanoparticles.Biomaterials science · 2013Article
- A programmable microenvironment for cellular studies via microfluidics-generated double emulsions.Biomaterials · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The future of genetic medicine hinges on successful intracellular delivery of nucleic acid-based therapeutics. While significant effort has concentrated on developing nanocarriers to improve the delivery aspects, scant attention has been paid to the synthetic process of poorly controlled nanocomplex formation. Proposed here is a reliable system to better control the complexation process, and thus the physical properties of the nanocomplexes, through microfluidics-assisted confinement (MAC) in picoliter droplets. We show that these homogeneous MAC-synthesized nanocomplexes exhibit narrower size distribution, lower cytotoxicity, and higher transfection efficiency compared to their bulk-synthesized counterparts. MAC represents a physical approach to control the energetic self-assembly of polyelectrolytes, thereby complementing the chemical innovations in nanocarrier design to optimize nucleic acid and peptide delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.