Evidence map›Paper›PMID 21506171›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2011

Nanoscale assembly in biological systems: from neuronal cytoskeletal proteins to curvature stabilizing lipids.

Cyrus R Safinya, Uri Raviv, Daniel J Needleman, Alexandra Zidovska, Myung Chul Choi, Miguel A Ojeda-Lopez, Kai K Ewert, Youli Li, Herbert P Miller, Joel Quispe and 5 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Tuning nanostructure dimensions with supramolecular twisting.The journal of physical chemistry. B · 2013
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Cyrus R SafinyaMaterials, Physics, and Molecular, Cellular, and Developmental Biology Departments, University of California-Santa Barbara, CA 93106, USA. safinya@mrl.ucsb.edu
Uri Raviv
Daniel J Needleman
Alexandra Zidovska
Myung Chul Choi
Miguel A Ojeda-Lopez
Kai K Ewert
Youli Li
Herbert P Miller
Joel Quispe
Bridget Carragher
Clinton S Potter
Mahn Won Kim
Stuart C Feinstein
Leslie Wilson
University of California, Santa Barbara · USScripps Research Institute · USKorea Advanced Institute of Science and Technology · KR

Funding

ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9M
ZERNIKE PHASE PLATE CRYOEM IN OKAZAKIP41RR002250 · NCRR · UNIVERSITY OF ARIZONA · PI CHIU, WAH · 1985 to 2011
$22.1M
WORKSHOPS AND TRAININGP41RR017573 · NCRR · SCRIPPS RESEARCH INSTITUTE, THE · PI CARRAGHER, BRIDGET OLIVIA · 2002 to 2011
$14.2M
Structures of Lipid-DNA Nonviral Gene Delivery Systems 4R01GM059288 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SAFINYA, CYRUS R · 1999 to 2016
$4.2M
Mechanism &Control of Brain Microtubule DynamicsR01NS013560 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI WILSON, LESLIE · 1985 to 2009
$2.9M
The Molecular Structure and Function of Tau ProteinR01NS035010 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI FEINSTEIN, STUART C · 1996 to 2010
$2.7M
NCRR NIH HHS P41 RR001209NCRR NIH HHS P41 RR002250NCRR NIH HHS P41 RR017573NCRR NIH HHS RR17573NIGMS NIH HHS GM-59288NIGMS NIH HHS R01 GM059288NINDS NIH HHS NS13560NINDS NIH HHS NS35010NINDS NIH HHS R01 NS013560NINDS NIH HHS R01 NS035010
6 · The paper itself

Abstract

The review will describe experiments inspired by the rich variety of bundles and networks of interacting microtubules (MT), neurofilaments, and filamentous-actin in neurons where the nature of the interactions, structures, and structure-function correlations remain poorly understood. We describe how three-dimensional (3D) MT bundles and 2D MT bundles may assemble, in cell free systems in the presence of counter-ions, revealing structures not predicted by polyelectrolyte theories. Interestingly, experiments reveal that the neuronal protein tau, an abundant MT-associated-protein in axons, modulates the MT diameter providing insight for the control of geometric parameters in bio- nanotechnology. In another set of experiments we describe lipid-protein-nanotubes, and lipid nano-tubes and rods, resulting from membrane shape evolution processes involving protein templates and curvature stabilizing lipids. Similar membrane shape changes, occurring in cells for the purpose of specific functions, are induced by interactions between membranes and proteins. The biological materials systems described have applications in bio-nanotechnology.

Indexed as

NanotechnologyActinsBiotechnologyCytoskeletal ProteinsLipidsLiposomesMicrotubulesNanotubesNeuronstau ProteinsActinsCytoskeletal ProteinsLipidsLiposomestau Proteins

Identifiers

PMID21506171
PMCPMC3864889
OpenAlexW1964958602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.