SynthesisIntensive care medicine2011
Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 11 registered trials, which are not on this map. Cited by 230 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Bedside Ultrasonographic Measurements of Optic Nerve Sheath Diameter Following the Return of Spontaneous Circulation Predict Negative Neurological Outcome in Out of Hospital Cardiac Arrest Patients?
Ultrasonographic Assessment of Optic Nerve Sheath Diameter in Children Receiving Caudal Block
Optical Nerve Sheath Diameter Changes During Steep Trendelenburg Position for Laparoscopic Prostatectomy
Comparison of Optic Nerve Sheath Diameters Measured by Optic Ultrasonography Before and After Lumbar Puncture in Idiopathic Intracranial Hypertension Patients
The Influence of Extracorporeal Circulation During Cardiac Surgery on Optic Nerve Sheath Diameter
The Impact of Invasive Intracranial Pressure Monitoring Guided Management on the Functional Outcomes of Patients With Supratentorial Large Volume Cerebral Hemorrhage: An Open Label, Randomized, Controlled, Multi-center Trial (BIATICH)
Comparison of the Effects of Intubation With a Machintosh Laryngoscope, McGrath Videolaryngoscope and C-Mac Videolaryngoscope on Intra-ocular Pressure, Optic Nerve Sheath Diameter and Haemodynamic Parameters
Monitoring Intracranial Pressure Change Via Optic Nerve Sheath Ultrasound During Electroconvulsive Therapy
Optic Nerve Sonography to Monitor Intracranial Pressure After Ischemic sTrokE - The ONSITE Study
Correlation Between Optic Nerve Sheath Diameter Measured by Ultrasound and Delirium in Cardiac Surgery
Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Assessed by Optic Nerve Sheath Diameter and Carotid Doppler Ultrasonography: a Prospective Observational Study
Who cites it
230 citing papers in PubMed, 4 syntheses or guidelines pooled it, 582 citations in OpenAlex.
- Sonographic optic nerve sheath diameter measurement for detecting intracranial hypertension in a suspected population: a systematic review and meta-analysis of diagnostic thresholds and influencing factors.Journal of neurology · 2026Pooled it
- Detection of intracranial hypertension in children using optical coherence tomography: a systematic review.BMJ open · 2021Pooled it
- Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis.Intensive care medicine · 2018Pooled it
- Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure during laparoscopic surgery: a systematic review and meta-analysis.Surgical endoscopy · 2018Pooled it
- Comparison of propofol and propofol-ketamine anesthesia on optic nerve sheath diameter in endovascular cerebral aneurysm procedures: a prospective randomized study.BMC anesthesiology · 2026Trial
- Association Between Local Anesthetic Volume-Dose Combinations and Optic Nerve Sheath Diameter as an Indirect Marker of Intracranial Pressure During Ultrasound-Guided Supraclavicular Brachial Plexus Block: A Randomized Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- Intraoperative optic nerve sheath diameter changes in vNOTES versus total laparoscopic hysterectomy: a prospective randomized study.Surgical endoscopy · 2026Trial
- Comparison of the Effects of Conventional and Piezoelectric Osteotomy on Intracranial Pressure Changes in Rhinoplasty Using Ultrasonographic Measurement of Optic Nerve Sheath Diameter.Aesthetic plastic surgery · 2026Trial
- Evaluating the effect of caudal epidural block on optic nerve sheath diameter in pediatric patients: randomized controlled study.BMC anesthesiology · 2025Trial
- Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol.Critical care (London, England) · 2021Trial
- The effect of laryngoscope types on hemodynamic response and optic nerve sheath diameter. McCoy, Macintosh, and C-MAC video-laryngoscope.Saudi medical journal · 2020Trial
- Epidural bolus versus continuous epidural infusion analgesia on optic nerve sheath diameter in paediatric patients: A prospective, double-blind, randomised trial.Scientific reports · 2020Trial
- Impact of controlled intraabdominal pressure on the optic nerve sheath diameter during laparoscopic procedures.Surgical endoscopy · 2016Trial
- Diagnostic and Prognostic Value of Sonographic Optic Nerve Sheath Diameter in Patients with Ischemic Stroke or Hypertensive Intracerebral Hemorrhage.Neurocritical care · 2026Article
- The Underutilized Ocular Fundus in Emergency Departments: Current Progress and Future Prospect of Imaging and Artificial Intelligence for Patient Care.Ophthalmology science · 2026Review
- Evaluation of CSF pressures, OCT parameters, and transorbital ultrasonographic measurements in ıdiopathic ıntracranial hypertension.International ophthalmology · 2026Article
- Longitudinal Peripartum Assessment of Retinal Nerve Fiber Layer Thickness and Optic Nerve Sheath Diameter in Women with Preeclampsia and Normotensive Pregnant Controls.Journal of clinical medicine · 2026Article
- 3D Freehand Ultrasound Imaging of Optic Nerve Sheath.Investigative radiology · 2026Article
- Semi-continuous non-invasive intracranial pressure monitoring via automated optic nerve sheath diameter image acquisition and analysis: a benchtop proof-of-concept study.International journal of computer assisted radiology and surgery · 2026Article
- Article
170 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the diagnostic accuracy of ultrasonography of optic nerve sheath diameter (ONSD) for assessment of intracranial hypertension.
methodsSystematic review without language restriction based on electronic databases, with manual review of literature and conference proceedings until July 2010. Studies were eligible if they compared ultrasonography of ONSD with intracranial pressure (ICP) monitoring. Data were extracted independently by three authors. Random-effects meta-analysis and meta-regression were performed.
resultsSix studies including 231 patients were reviewed. No significant heterogeneity was detected for sensitivity, specificity, positive and negative likelihood ratios or diagnostic odds ratio. For detection of raised intracranial pressure, pooled sensitivity was 0.90 [95% confidence interval (CI) 0.80-0.95; p for heterogeneity, p (het) = 0.09], pooled specificity was 0.85 (95% CI 0.73-0.93, p (het) = 0.13), and the pooled diagnostic odds ratio was 51 (95% CI 22-121). The area under the summary receiver-operating characteristic (SROC) curve was 0.94 (95% CI 0.91-0.96).
conclusionsUltrasonography of ONSD shows a good level of diagnostic accuracy for detecting intracranial hypertension. In clinical decision-making, this technique may help physicians decide to transfer patients to specialized centers or to place an invasive device when specific recommendations for this placement do not exist.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.