ArticleEndocrine2011
Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism.
Article in Endocrine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02090907 (Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Low-normal free thyroxine is associated with a higher prevalence of lower extremity arterial disease in euthyroid type 2 diabetes mellitus.Scientific reports · 2025Article
- Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism.Thyroid research · 2024Review
- Unknown Subclinical Hypothyroidism and In-Hospital Outcomes and Short- and Long-Term All-Cause Mortality among ST Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention.Journal of clinical medicine · 2020Article
- The impact of thyroid hormone dysfunction on ischemic heart disease.Endocrine connections · 2019Review
- Relationship between thyroid function and elevated blood pressure in euthyroid adults.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- The relationship between circulating TRAIL and endothelial dysfunction in subclinical hypothyroidism.Endocrine · 2015Article
- Article
- Mechanism of subclinical hypothyroidism accelerating endothelial dysfunction (Review).Experimental and therapeutic medicine · 2015Article
- Thyroid Function, Prevalent Coronary Heart Disease, and Severity of Coronary Atherosclerosis in Patients Undergoing Coronary Angiography.International journal of endocrinology · 2015Article
- Thyroid and the heart.The American journal of medicine · 2014Review
- Raised serum TSH in morbid-obese and non-obese patients: effect on the circulating lipid profile.Endocrine · 2014Article
- Subclinical hypothyroidism is associated with elevated high-sensitive C-reactive protein among adult Taiwanese.Endocrine · 2013Article
- Therapeutic approach in the improvement of endothelial dysfunction: the current state of the art.BioMed research international · 2013Review
- Postprandial lipaemia suppresses endothelium-dependent arterial dilation in patients with hypothyroidism.Endocrine · 2012Article
- Endothelial dysfunction and subclinical hypothyroidism: a brief review.Journal of endocrinological investigation · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (FT4), free T3 (FT3) levels and increased serum thyroid-stimulating hormone (TSH) levels. Endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. The aim of this study is to evaluate endothelial functions and the effect of L-thyroxin (L-T4) therapy on endothelial functions in SH. Twenty-seven patients with SH and 22 healthy controls were evaluated in terms of endothelial functions, using brachial artery Doppler ultrasonography. After restorating euthyroidism, measurements were repeated. Baseline and nitroglycerin induced diameter (NID) of brachial artery were similar in patients with SH and the control group. Compared to the control group, the patients with SH showed significantly reduced flow-mediated diameter (FMD). Baseline and NID values were significantly higher after LT4 therapy in SH group. FMD also significantly increased after LT4 therapy. Hypothyroidism accelerates atherogenesis through modification of atherosclerotic risk factors and direct effects on the blood vessels. In this study, we observed marked improvement in endothelial functions after L-T4 therapy in SH patients. We suggest that thyroid hormone replacement therapy may help to prevent atherosclerosis in this group of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.