ArticleJournal of bioenergetics and biomembranes2011
Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver.
Article in Journal of bioenergetics and biomembranes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Methionine Restriction Differentially Modulates Expression of Genes in the Base Excision Repair Pathway in Rat Brain and Liver.Biomolecules · 2025Article
- Melatonin Attenuates Calcium Deposition from Vascular Smooth Muscle Cells by Activating Mitochondrial Fusion and Mitophagy via an AMPK/OPA1 Signaling Pathway.Oxidative medicine and cellular longevity · 2020Article
- Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species.Journal of molecular biology · 2018Review
- Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions.The Journal of biological chemistry · 2017Review
- An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats.Nutrients · 2017Article
- Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans.Free radical biology & medicine · 2015Review
- The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction.Physiological research · 2014Article
- The effects of dietary restriction on oxidative stress in rodents.Free radical biology & medicine · 2014Review
- Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations.Life sciences · 2013Article
- The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction.Bioscience reports · 2012Article
- Midlife gene expressions identify modulators of aging through dietary interventions.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Calorie restriction (CR) has been shown to decrease H(2)O(2) production in liver mitochondria, although it is not known if this is due to uniform changes in all mitochondria or changes in particular mitochondrial sub-populations. To address this issue, liver mitochondria from control and CR mice were fractionated using differential centrifugation at 1,000 g, 3,000 g and 10,000 g into distinct populations labeled as M1, M3 and M10, respectively. Mitochondrial protein levels, respiration and H(2)O(2) production were measured in each fraction. CR resulted in a decrease in total protein (mg) in each fraction, although this difference disappeared when adjusted for liver weight (mg protein/g liver weight). No differences in respiration (State 3 or 4) were observed between control and CR mice in any of the mitochondrial fractions. CR decreased H(2)O(2) production in all fractions when mitochondria respired on succinate (Succ), succ+antimycin A (Succ+AA) or pyruvate/malate+rotenone (P/M+ROT). Thus, CR decreased reactive oxygen species (ROS) production under conditions which stimulate mitochondrial complex I ROS production under both forward (P/M+ROT) and backward (Succ & Succ+AA) electron flow. The results indicate that CR decreases H(2)O(2) production in all liver mitochondrial fractions due to a decrease in capacity for ROS production by complex I of the electron transport chain.
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