ArticleCancer microenvironment : official journal of the International Cancer Microenvironment Society2011
Differential Inductive Signaling of CD90 Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells.
Article in Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Interpretable machine learning driven biomarker identification and validation for prostate cancer.Translational andrology and urology · 2025Article
- Prostate cancer research: tools, cell types, and molecular targets.Frontiers in oncology · 2024Review
- Role and mechanism of CD90Molecular medicine (Cambridge, Mass.) · 2023Review
- The opposing action of stromal cell proenkephalin and stem cell transcription factors in prostate cancer differentiation.BMC cancer · 2021Article
- Selection and Evaluation of Specific Single Chain Antibodies against CD90, a Marker for Mesenchymal and Cancer Stem Cells.Reports of biochemistry & molecular biology · 2018Article
- Multiple roles of CD90 in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells.Stem cell research & therapy · 2016Article
- PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Reprogramming of prostate cancer cells--technical challenges.Current urology reports · 2015Review
- Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.PloS one · 2013Article
- Bladder expression of CD cell surface antigens and cell-type-specific transcriptomes.Cell and tissue research · 2012Article
- Lineage relationship of prostate cancer cell types based on gene expression.BMC medical genomics · 2011Article
- Isolation and analysis of discreet human prostate cellular populations.Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
Abstract
unlabelledProstate carcinomas are surrounded by a layer of stromal fibroblastic cells that are characterized by increased expression of CD90. These CD90(+) cancer-associated stromal fibroblastic cells differ in gene expression from their normal counterpart, CD49a(+)CD90(lo) stromal smooth muscle cells; and were postulated to represent a less differentiated cell type with altered inductive properties. CD90(+) stromal cells were isolated from tumor tissue specimens and co-cultured with the pluripotent embryonal carcinoma cell line NCCIT in order to elucidate the impact of tumor-associated stroma on stem cells, and the 'cancer stem cell.' Transcriptome analysis identified a notable decreased induction of smooth muscle and prostate stromal genes such as PENK, BMP2 and ChGn compared to previously determined NCCIT response to normal prostate stromal cell induction. CD90(+) stromal cell secreted factors induced an increased expression of CD90 and differential induction of genes involved in extracellular matrix remodeling and the RECK pathway in NCCIT. These results suggest that, compared to normal tissue stromal cells, signaling from cancer-associated stromal cells has a markedly different effect on stem cells as represented by NCCIT. Given that stromal cells are important in directing organ-specific differentiation, stromal cells in tumors appear to be defective in this function, which may contribute to abnormal differentiation found in diseases such as cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12307-010-0061-4) contains supplementary material, which is available to authorized users.
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Registered trials
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