ArticleNature communications2011
Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- POCA: a CPG signal analysis algorithm using peak-based feature extraction and machine learning.Frontiers in neuroscience · 2026Article
- Review
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter.Scientific reports · 2023Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.Frontiers in human neuroscience · 2022Article
- Computational Modeling of Spinal Locomotor Circuitry in the Age of Molecular Genetics.International journal of molecular sciences · 2021Review
- Mapping the Dynamic Recruitment of Spinal Neurons during Fictive Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Pedal serotonergic neuron clusters of the pteropod mollusc, Clione limacina, contain two morphological subtypes with different innervation targets.Invertebrate neuroscience : IN · 2020Article
- Neuromodulatory Selection of Motor Neuron Recruitment Patterns in a Visuomotor Behavior Increases Speed.Current biology : CB · 2020Article
- Biological data questions the support of the self inhibition required for pattern generation in the half center model.PloS one · 2020Article
- Contribution of 5-HTFrontiers in neural circuits · 2020Article
- Large-Scale Analysis of the Diversity and Complexity of the Adult Spinal Cord Neurotransmitter Typology.iScience · 2019Article
- Article
- Transplantation of Neural Progenitors and V2a Interneurons after Spinal Cord Injury.Journal of neurotrauma · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequencies. Here we explore the mechanisms driving this frequency-dependent role using four methods to determine how V2a interneurons are recruited at different locomotor frequencies. We show that half of the V2a interneurons receive rhythmic locomotor synaptic drive, which increases with cycle frequency, recruiting more of the neurons to fire at higher frequencies. The other V2a interneurons do not receive locomotion-related synaptic drive and are not recruited into the locomotor network at any frequency. The increased role of V2a interneurons at higher locomotor frequencies arises from increased synaptic drive to recruit subthreshold oscillating V2a neurons, and not from recruitment of a second set of silent V2a interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.