Evidence map›Paper›PMID 21505320›Full record

ArticleAIDS (London, England)2011

Selection of nonnucleoside reverse transcriptase inhibitor-associated mutations in HIV-1 subtype C: evidence of etravirine cross-resistance.

Ujjwal Neogi, Anita Shet, Ranjani Shamsundar, Maria L Ekstrand

Abstract read
In one paragraph

Article in AIDS (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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  4. Pretreatment HIV drug resistance among adults initiating ART in Namibia.The Journal of antimicrobial chemotherapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Ujjwal NeogiSt John's National Academy of Health Sciences, Bangalore, India.
Anita Shet
Ranjani Shamsundar
Maria L Ekstrand
St. John's National Academy of Health Sciences · INSan Francisco AIDS Foundation · US

Funding

Examining ART Adherence Issues in Bangalore IndiaR01MH067513 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EKSTRAND, MARIA L. · 2003 to 2010
$2.9M
Enhancing HIV treatment adherence in Bangalore: The Chetana studyR01MH095659 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EKSTRAND, MARIA L. · 2011 to 2016
$2.4M
NIMH NIH HHS R01 MH067513NIMH NIH HHS R01 MH095659
6 · The paper itself

Abstract

Prevalence of etravirine genotypic resistance was assessed among 92 HIV-1C-infected patients failing nevirapine and efavirenz-based regimens from a cohort of 552 Indian patients. Overall, prevalence of etravirine cross-resistance identified using the Tibotec Weighted Score was 41% (31.5% intermediately-resistant and 9.8% fully-resistant). The most frequently described nonnucleoside reverse transcriptase inhibitor-associated mutations included Y181 (35.9%), K101 (20.7%), G190 (17.4%), and V108 (15.2%). The resistant group demonstrated higher viral load (P = 0.01) and longer duration of antiretroviral treatment (P = 0.03) compared with the susceptible group.

Indexed as

Drug Resistance, ViralHIV-1HIV InfectionsHumansMutationNitrilesPyridazinesPyrimidinesReverse Transcriptase InhibitorsetravirineNitrilesPyridazinesPyrimidinesReverse Transcriptase Inhibitors

Identifiers

PMID21505320
PMCPMC3637935
OpenAlexW2163315037

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.