Do calcium plus vitamin D supplements increase cardiovascular risk?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis.Medicine · 2017
   Pooled it
2. A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
   Pooled it
3. Prophylaxis of Pain and Fractures within Feet in the Course of Osteoporosis: The Issue of Diagnosing.Pain research & management · 2020
   Review
4. The calcium and vitamin D controversy.Therapeutic advances in musculoskeletal disease · 2017
   Review
5. The predicted lifetime costs and health consequences of calcium and vitamin D supplementation for fracture prevention-the impact of cardiovascular effects.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
   Article
6. Calcium supplement intake and risk of cardiovascular disease in women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
   Article
7. Osteoporosis and fracture risk in older people.Clinical medicine (London, England) · 2014
   Article
8. Clinical practice. Calcium supplements and fracture prevention.The New England journal of medicine · 2013
   Review
9. Calcium supplements and cardiovascular risk: 5 years on.Therapeutic advances in drug safety · 2013
   Review
10. The role of vitamin D supplementation in patients with rheumatic diseases.Nature reviews. Rheumatology · 2013
    Review
11. Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study).The American journal of cardiology · 2012
    Article

Corrections and comments

• Commented on by
  Authors' response to editorial.2011
• Comment on
  Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis.2011

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as