ArticleDiabetes care2011
Accuracy of the Neuropad test for the diagnosis of distal symmetric polyneuropathy in type 2 diabetes.
Article in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Natural therapy proposed for the management of diabetic peripheral neuropathy (DPN).Inflammopharmacology · 2025Review
- Screening for diabetic peripheral neuropathy in resource-limited settings.Diabetology & metabolic syndrome · 2023Review
- Frontiers in diagnostic and therapeutic approaches in diabetic sensorimotor neuropathy (DSPN).Frontiers in endocrinology · 2023Review
- Preulcerous Risk Situation in Diabetic Foot Syndrome: Proposal for a Simple Ulcer Prevention Score.Journal of diabetes science and technology · 2021Article
- Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres.Diagnostics (Basel, Switzerland) · 2021Review
- Current View of Diagnosing Small Fiber Neuropathy.Journal of neuromuscular diseases · 2021Review
- Dryness of Foot Skin Assessed by the Visual Indicator Test and Risk of Diabetic Foot Ulceration: A Prospective Observational Study.Frontiers in endocrinology · 2020Observational
- Evaluation of sural nerve automated nerve conduction study in the diagnosis of peripheral neuropathy in patients with type 2 diabetes mellitus.Archives of medical science : AMS · 2016Article
- [Diabetic neuropathy].Wiener klinische Wochenschrift · 2016Review
- Automated Quantification of Neuropad Improves Its Diagnostic Ability in Patients with Diabetic Neuropathy.Journal of diabetes research · 2015Article
- The diagnostic accuracy of Neuropad for assessing large and small fibre diabetic neuropathy.Diabetic medicine : a journal of the British Diabetic Association · 2014Article
- New vistas in the diagnosis of diabetic polyneuropathy.Endocrine · 2014Review
- Correlation between sudomotor function, sweat gland duct size and corneal nerve fiber pathology in patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2014Article
- Advances in the diagnosis and management of diabetic distal symmetric polyneuropathy.Archives of medical science : AMS · 2014Article
- Increased serum levels of uric acid are associated with sudomotor dysfunction in subjects with type 2 diabetes mellitus.Experimental diabetes research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the accuracy of Neuropad for the diagnosis and staging of distal symmetric polyneuropathy (DPN) across different stages of neuropathy, using multiple-level likelihood ratios (LRs) to interpret the time necessary to complete the color change of the test. RESEARCH DESIGN AND
methodsWe conducted a cross-sectional, cohort-type diagnostic accuracy study in 251 consecutive adult type 2 diabetic patients with no peripheral arterial disease or other potential causes of neuropathy, who were recruited between January 2005 and December 2008 from the diabetes outpatient clinics in Alexandroupolis Hospital, Greece. Patients were tested for DPN by means of the neuropathy disability score (NDS) and Neuropad. Multiple-level LRs for time to complete color change were calculated across different stages of neuropathy.
resultsThe areas under the curve for the diagnosis of any (NDS of ≥3), at least moderate (NDS of ≥6), or severe (NDS of ≥9) DPN were 0.91, 0.96, and 0.97, respectively. The calculation of multiple-level LRs showed that time to complete color change <360 s suggested the absence of neuropathy. Values between 360 and 1,000 s were indicative of mild neuropathy. Finally, values between 1,000 and 1,200 or >1,200 s were strongly suggestive of moderate or severe DPN, respectively.
conclusionsNeuropad could be used as a triage test for the diagnosis and staging of DPN in patients with type 2 diabetes, prompting referral to specialized care setting.
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