ReviewBlood2011
Immunodeficiency lentiviral infections in natural and non-natural hosts.
Review in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study ofViruses · 2024Article
- HIHISIV: a database of gene expression in HIV and SIV host immune response.BMC bioinformatics · 2024Article
- Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection.JCI insight · 2021Article
- Impact of human immunodeficiency virus on pulmonary vascular disease.Global cardiology science & practice · 2021Review
- Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology.Journal of virology · 2019Article
- Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children.Frontiers in immunology · 2019Article
- Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies.Frontiers in immunology · 2018Review
- Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction.Journal of virology · 2017Article
- Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- HIV persists in CCR6+CD4+ T cells from colon and blood during antiretroviral therapy.AIDS (London, England) · 2017Article
- Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.Journal of virus eradication · 2016Article
- Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.PLoS pathogens · 2016Article
- Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques.PLoS pathogens · 2016Article
- Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.Nature methods · 2015Article
- T memory stem cells and HIV: a long-term relationship.Current HIV/AIDS reports · 2015Review
- Animal models in HIV cure research.Journal of virus eradication · 2015Review
- Article
- Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Factors associated with siman immunodeficiency virus transmission in a natural African nonhuman primate host in the wild.Journal of virology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The host immune system is profoundly affected during the acute phase of progressive immunodeficiency lentiviral infections. Studies of these alterations have been quite restricted in humans because of the limited availability of samples from acutely HIV-infected persons. Therefore, numerous studies have turned attention to nonhuman primate models. Specifically, SIV-infected rhesus macaques (RMs) have been informative for understanding the pathogenesis of HIV infection in humans. Indeed, advantages of the nonhuman primate model include the ability to study the very early events after infection and the ability to retrieve copious amounts of tissues. In addition, nonhuman primates allow for comparative studies between non-natural and natural hosts for SIV, in which SIV infection results in progression, or not, to AIDS, respectively. Although SIV infection of RM is the best model for HIV infection, the immunologic and/or virologic phenomena in SIV-infected RM do not always reflect those seen in HIV-infected humans. Here virologic and immunologic aspects of acute HIV infection of humans and SIV infection of Asian and African nonhuman primates are discussed and compared in relation to how these aspects relate to disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.