ArticleBlood2011
STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- ATP/P2X7 receptor signal aggravates ischemic stroke injury by activating Th17 cells via STAT3/IL-21 pathway.Frontiers in immunology · 2025Article
- The identification and expression of an interleukin-21 receptor in large yellow croaker (Larimichthys crocea).Molecular biology reports · 2023Article
- Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability.Journal of virology · 2022Article
- Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf.Cell reports · 2019Article
- Th9 and other IL-9-producing cells in allergic asthma.Seminars in immunopathology · 2017Review
- [Research advances in the role of interleukin-21 in chronic hepatitis B virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016Review
- Expression levels of IL-17 and TNF-α in degenerated lumbar intervertebral discs and their correlation.Experimental and therapeutic medicine · 2016Article
- Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the bone marrow of normal and lupus mice.Clinical immunology (Orlando, Fla.) · 2016Article
- Poly-ADP-ribosyl polymerase-14 promotes T helper 17 and follicular T helper development.Immunology · 2015Article
- Article
- Genetic association of IL-21 polymorphisms with dilated cardiomyopathy in a Han Chinese population.Herz · 2015Article
- The development and in vivo function of T helper 9 cells.Nature reviews. Immunology · 2015Review
- Th9 cell development requires a BATF-regulated transcriptional network.The Journal of clinical investigation · 2013Article
- Article
- Th9 cells: differentiation and disease.Immunological reviews · 2013Review
- Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function.Annals of the New York Academy of Sciences · 2012Review
- Article
- The symphony of the ninth: the development and function of Th9 cells.Current opinion in immunology · 2012Review
- STAT6-dependent regulation of Th9 development.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
The contribution of specific cell types to the production of cytokines that regulate hematopoiesis is still not well defined. We have previously identified T cell-dependent regulation of hematopoietic progenitor cell (HPC) numbers and cycling. In this report, we demonstrated that HPC activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not because of decreased expression of IL-17 or RORγt. STAT3 expression in T cells was required for IL-21 production by multiple T helper subsets, and neutralization of IL-21 resulted in decreased HPC activity identical to that in mice with STAT3-deficient T cells. Importantly, injection of IL-21 rescued HPC activity in mice with STAT3-deficient T cells. Thus, STAT3-dependent IL-21 production in T cells is required for HPC homeostasis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.