ArticleHistochemistry1990
Expression of an alpha cardiac-like myosin heavy chain in muscle spindle fibres.
Article in Histochemistry, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Co-expression of MyHC-15 with other known isoforms in rat muscle spindles.European journal of histochemistry : EJH · 2025Article
- Degeneration of muscle spindles in a murine model of Pompe disease.Scientific reports · 2023Article
- The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy.The Journal of physiology · 2019Article
- Fibre typing of intrafusal fibres.Journal of anatomy · 2015Review
- Tissue engineering intrafusal fibers: dose- and time-dependent differentiation of nuclear bag fibers in a defined in vitro system using neuregulin 1-beta-1.Biomaterials · 2008Article
- Expression of Myosin heavy chain isoforms in rat soleus muscle spindles after 19 days of hypergravity.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2003Article
- Muscle fibre types in the suprahyoid muscles of the rat.Journal of anatomy · 2001Article
- Identification of alpha-cardiac myosin heavy chain mRNA and protein in extraocular muscle of the adult rabbit.Journal of muscle research and cell motility · 1994Article
- Sequences of intrafusal fiber formation are muscle-dependent in rat hindlimbs.Anatomy and embryology · 1994Article
- Development of chicken intrafusal muscle fibers.Cell and tissue research · 1993Article
- Transient expression of a slow-tonic MHC isoform by extrafusal fibers in the developing rat.Anatomy and embryology · 1993Article
- Transient expression of a ventricular myosin heavy chain isoform in developing chicken intrafusal muscle fibers.Histochemistry · 1993Article
- Article
- Myosin heavy chain expression in rabbit masseter muscle during postnatal development.Journal of anatomy · 1992Article
- Rat muscle spindle immunocytochemistry revisited.Histochemistry · 1991Article
- Generating intrafusal skeletal muscle fibresJournal of tissue engineeringReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study we have investigated the reactivity of rat muscle to a specific monoclonal antibody directed against alpha cardiac myosin heavy chain. Serial cross sections of rat hindlimb muscles from the 17th day in utero to adulthood, and after neonatal denervation and de-efferentation, were studied by light microscope immunohistochemistry. Staining with anti-alpha myosin heavy chain was restricted to intrafusal bag fibres in all specimens studied. Nuclear bag2 fibres were moderately to strongly stained in the intracapsular portion and gradually lost their reactivity towards the ends, whereas nuclear bag1 fibres were stained for a short distance in each pole. Nuclear bag2 fibres displayed reactivity to anti-alpha myosin heavy chain from the 21st day of gestation, whereas nuclear bag1 fibres only acquired reactivity to anti-alpha myosin heavy chain three days after birth. After neonatal de-efferentation, the reactivity of nuclear bag2 fibres to anti-alpha myosin heavy chain was decreased and limited to a shorter portion of the fibre, whereas nuclear bag1 fibres were unreactive. We showed that a myosin heavy chain isoform hitherto unknown for skeletal muscle is specifically expressed in rat nuclear bag fibres. These findings add further complexity to the intricate pattern of isomyosin expression in intrafusal fibres. Furthermore, we show that motor innervation influences the expression of this isomyosin along the length of the fibres.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.