ReviewSchizophrenia bulletin2011
Age of onset of schizophrenia: perspectives from structural neuroimaging studies.
Review in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Effect of n-3 polyunsaturated fatty acids on the treatment of schizophrenia: an updated systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Post-incident debriefing for people with schizophrenia after coercive measures.The Cochrane database of systematic reviews · 2025Pooled it
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Pooled it
- Association of Attention-Deficit/Hyperactivity Disorder in Childhood and Adolescence With the Risk of Subsequent Psychotic Disorder: A Systematic Review and Meta-analysis.JAMA psychiatry · 2021Pooled it
- Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021Pooled it
- Psychological interventions for psychosis in adolescents.The Cochrane database of systematic reviews · 2020Pooled it
- Smartphone Apps to Support Coordinated Specialty Care for Prodromal and Early Course Schizophrenia Disorders: Systematic Review.Journal of medical Internet research · 2019Pooled it
- A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia.Molecular psychiatry · 2017Pooled it
- Meta-analysis of Cognitive Impairment in First-Episode Bipolar Disorder: Comparison With First-Episode Schizophrenia and Healthy Controls.Schizophrenia bulletin · 2015Pooled it
- Pooled it
- Atypical antipsychotics for psychosis in adolescents.The Cochrane database of systematic reviews · 2013Pooled it
- Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Pooled it
- Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis.JAMA psychiatry · 2023Trial
- Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans.Journal of psychiatry & neuroscience : JPN · 2017Trial
- Functional genomic profiling of schizophrenia-associated genes reveals key microglial regulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Xanomeline-Trospium Validates Muscarinic Agonism as an Effective Non-Dopaminergic Treatment for Schizophrenia.International journal of molecular sciences · 2026Review
- Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Early Trajectories of Suicidality in Adolescents and Young Adults: A Retrospective Study from a Community Mental Health Facility in Northern Italy.Clinics and practice · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of onset in late adolescence. Late adolescence may reflect a critical period in brain development making it particularly vulnerable for the onset of psychopathology. Neuroimaging studies that focus on this age range may provide unique insights into the onset and course of psychosis. In this review, we examine the evidence from 2 unique longitudinal cohorts that span the ages from early childhood through young adulthood; a study of childhood-onset schizophrenia where patients and siblings are followed from ages 6 through to their early twenties, and an ultra-high risk study where subjects (mean age of 19 years) are studied before and after the onset of psychosis. From the available evidence, we make an argument that subtle, regionally specific, and genetically influenced alterations during developmental age windows influence the course of psychosis and the resultant brain phenotype. The importance of examining trajectories of development and the need for future combined approaches, using multimodal imaging together with molecular studies is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.