ArticleProceedings of the National Academy of Sciences of the United States of America2011
Spreading dynamics and wetting transition of cellular aggregates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 170 citations in OpenAlex.
- Label-free all-electrical tracking of individual and collective cell migration on a megapixel CMOS capacitance sensor.Lab on a chip · 2026Article
- Tissue flow acts as a guidance cue for immune cell polarization and directional migration.Nature cell biology · 2026Article
- What is active wetting?The European physical journal. E, Soft matter · 2026Review
- Mechanisms of active wetting and fluidification in epithelial cell collectives.Nature materials · 2026Article
- Label-Free All-Electrical Tracking of Individual and Collective Cell Migration on a Megapixel CMOS Capacitance Sensor.bioRxiv : the preprint server for biology · 2026Article
- Beyond the membrane: rethinking EGFR signaling in physiology and cancer.Cellular and molecular life sciences : CMLS · 2026Review
- Active foam dynamics of tissue spheroid fusion.Nature communications · 2025Article
- RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Soft matter mechanics of immune cell aggregates.Journal of the Royal Society, Interface · 2025Article
- A pattern of villification.Nature materials · 2024Article
- Article
- Different contractility modes control cell escape from multicellular spheroids and tumor explants.APL bioengineering · 2024Article
- Confinement induces internal flows in adherent cell aggregates.Journal of the Royal Society, Interface · 2024Article
- Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.Nature communications · 2024Article
- SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces.Molecular biology of the cell · 2023Article
- Embryo-uterine interaction coordinates mouse embryogenesis during implantation.The EMBO journal · 2023Article
- Patterning and folding of intestinal villi by active mesenchymal dewetting.bioRxiv : the preprint server for biology · 2023Article
- Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters.Communications biology · 2023Article
- Active wetting of epithelial tissues: modeling considerations.European biophysics journal : EBJ · 2023Review
- Mechanical stress driven by rigidity sensing governs epithelial stability.Nature physics · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We study the spreading of spheroidal aggregates of cells, expressing a tunable level of E-cadherin molecules, on glass substrates decorated with mixed fibronectin and polyethylene glycol. We observe the contact area by optical interferometry and the profile by side-view microscopy. We find a universal law of aggregate spreading at short times, which we interpret through an analogy with the spreading of viscoelastic droplets. At long times, we observe either partial wetting or complete wetting, with a precursor film of cells spreading around the aggregate with two possible states. In strongly cohesive aggregates this film is a cellular monolayer in the liquid state, whereas in weakly cohesive aggregates, cells escape from the aggregate, forming a 2D gas. The escape of isolated cells is a physical mechanism that appears also to be present in the progression of a noninvasive tumor into a metastatic malignant carcinoma, known as the epithelial-mesenchymal transition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.