ArticleThe Journal of biological chemistry2011
Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Distinct regulatory states control the elongation of individual skeletal rods in the sea urchin embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- FoxO6 regulates Hippo signaling and growth of the craniofacial complex.PLoS genetics · 2018Article
- Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.Cell death & disease · 2017Article
- Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation.Developmental biology · 2017Article
- Role of MIZ-1 inBiochemistry and biophysics reports · 2016Article
- TBX1 protein interactions and microRNA-96-5p regulation controls cell proliferation during craniofacial and dental development: implications for 22q11.2 deletion syndrome.Human molecular genetics · 2015Article
- A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome.Human molecular genetics · 2014Article
- MSX2 in ameloblast cell fate and activity.Frontiers in physiology · 2014Review
- The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.Development (Cambridge, England) · 2013Article
- Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.Journal of cellular and molecular medicine · 2013Article
- Dact2 represses PITX2 transcriptional activation and cell proliferation through Wnt/beta-catenin signaling during odontogenesis.PloS one · 2013Article
- Retinoic acid expands the evolutionarily reduced dentition of zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Regulation of calbindin-D(28k) expression by Msx2 in the dental epithelium.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.PloS one · 2012Article
- Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19.American journal of human genetics · 2011Article
- From molecules to mastication: the development and evolution of teeth.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
FoxJ1 is a forkhead transcription factor expressed in multiple tissues during development and a major regulator of cilia development. FoxJ1(-/-) mice present with defects in odontogenesis, and we correlate these defects to hierarchical interactions between homeodomain factors Pitx2 and Dlx2 with FoxJ1 in regulating their expression through direct physical interactions. Chromatin immunoprecipitation assays reveal endogenous Pitx2 and Dlx2 binding to the Dlx2 promoter and Dlx2 binding to the FoxJ1 promoter as well as Dlx2 and FoxJ1 binding to the amelogenin promoter. PITX2 activation of the Dlx2 promoter is attenuated by a direct Dlx2 physical interaction with PITX2. Dlx2 autoregulates its promoter, and Dlx2 transcriptionally activates the downstream gene FoxJ1. Dlx2 and FoxJ1 physically interact and synergistically regulate both Dlx2 and FoxJ1 promoters. Dlx2 and FoxJ1 also activate the amelogenin promoter, and amelogenin is required for enamel formation and late stage tooth development. FoxJ1(-/-) mice maxillary and mandibular incisors are reduced in length and width and have reduced amelogenin expression. FoxJ1(-/-) mice show a reduced and defective ameloblast layer, revealing a biological effect of these transcription factor hierarchies during tooth morphogenesis. These transcriptional mechanisms may contribute to other developmental processes such as neuronal, pituitary, and heart development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.