ArticlePhysiology & behavior2011
Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats.
Article in Physiology & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis.Psychopharmacology · 2021Pooled it
- Pharmacokinetics of repeated, high-dose fentanyl administration in rats.Drug metabolism and disposition: the biological fate of chemicals · 2026Article
- Article
- Hematological and biochemical characterization of aging farm male rat strains in the national center for geriatrics and gerontology.Experimental animals · 2025Article
- Strain-Dependent Differences in Inflammatory/Immune Activity in Cutaneous Wound Tissue Repair in Rats: The Significance of Body Mass/Proneness to Obesity.Mediators of inflammation · 2025Article
- Streptozotocin as a tool for induction of rat models of diabetes: a practical guide.EXCLI journal · 2023Review
- Modelling the effects of variability in feeding rate on growth - a vital step for DEB-TKTD modelling.Ecotoxicology and environmental safety · 2022Article
- Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population.G3 (Bethesda, Md.) · 2021Article
- The laboratory rat: Age and body weight matter.EXCLI journal · 2021Review
- Article
- Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice.Biochemical pharmacology · 2019Article
- The translation of age-related body composition findings from rodents to humans.European journal of clinical nutrition · 2019Review
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.PloS one · 2015Article
- Age-related declines in thirst and salt appetite responses in male Fischer 344×Brown Norway rats.Physiology & behavior · 2014Article
- The heme oxygenase system rescues hepatic deterioration in the condition of obesity co-morbid with type-2 diabetes.PloS one · 2013Article
- Rat chromosome 8 confers protection against dyslipidemia caused by a high-fat/low-carbohydrate diet.Journal of nutrigenetics and nutrigenomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The goal of this study was to determine the adiposity of a range of rat strains, including a panel of consomics, to estimate heritability. To that end, we assessed the body fat distribution and organ weights of groups of adult male rats from 3 outbred strains, 11 inbred strains and 22 consomic strains. We measured the weights of the gonadal, retroperitoneal, mesenteric, femoral, subscapular and pericardial white fat depots, the subscapular brown fat depot, the kidneys, liver, heart, spleen, and brain. Strains were compared for the measured weight of each of these adipose depots and organs, and also for these weights adjusted statistically for body size. All individual adipose depot and organ weights were highly heritable, in most cases h(2)>0.50. The fourteen inbred and outbred rat strains were not very different in body length but there was a three-fold difference in body weight, and up to a twenty-fold difference in the weight of some adipose depots. Comparison of the FHH-Chr n(BN) consomic strains with the FHH host strain revealed 98 quantitative trait loci (QTLs) for body composition and organ weight, with the introgressed chromosome reducing weight or adiposity in most cases. These results can be used to guide the choice of appropriate rat strains for future studies of the genetic architecture of obesity and body size.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.