ArticleBiophysical journal2011
Dynamics of the bacterial flagellar motor: the effects of stator compliance, back steps, temperature, and rotational asymmetry.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings.Frontiers in microbiology · 2022Article
- Mechanosensitive remodeling of the bacterial flagellar motor is independent of direction of rotation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Multi-bit Boolean model for chemotactic drift ofIET systems biology · 2020Article
- Measurement of the Internal Frictional Drag of the Bacterial Flagellar Motor by Fluctuation Analysis.Biophysical journal · 2020Article
- Design principles and optimal performance for molecular motors under realistic constraints.Physical review. E · 2018Article
- The Limiting Speed of the Bacterial Flagellar Motor.Biophysical journal · 2016Article
- Mechanics of torque generation in the bacterial flagellar motor.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dynamics of mechanosensing in the bacterial flagellar motor.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Stochastic coordination of multiple actuators reduces latency and improves chemotactic response in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The rotation of a bacterial flagellar motor (BFM) is driven by multiple stators tethered to the cell wall. Here, we extend a recently proposed power-stroke model to study the BFM dynamics under different biophysical conditions. Our model explains several key experimental observations and reveals their underlying mechanisms. 1), The observed independence of the speed at low load on the number of stators is explained by a force-dependent stepping mechanism that is independent of the strength of the stator tethering spring. Conversely, without force-dependent stepping, an unrealistically weak stator spring is required. 2), Our model with back-stepping naturally explains the observed absence of a barrier to backward rotation. Using the same set of parameters, it also explains BFM behaviors in the high-speed negative-torque regime. 3), From the measured temperature dependence of the maximum speed, our model shows that stator-stepping is a thermally activated process with an energy barrier. 4), The recently observed asymmetry in the torque-speed curve between counterclockwise- and clockwise-rotating BFMs can be quantitatively explained by the asymmetry in the stator-rotor interaction potentials, i.e., a quasilinear form for the counterclockwise motor and a quadratic form for the clockwise motor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.