ArticleMolecular brain2011
Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila.
Article in Molecular brain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells.FEBS open bio · 2026Article
- TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions.Brain : a journal of neurology · 2024Article
- DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion.The EMBO journal · 2022Article
- A new model for fatty acid hydroxylase-associated neurodegeneration reveals mitochondrial and autophagy abnormalities.Frontiers in cell and developmental biology · 2022Article
- A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.PLoS genetics · 2020Article
- Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.PLoS genetics · 2020Article
- Article
- Exploring genetic modifiers of Gaucher disease: The next horizon.Human mutation · 2018Review
- SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.Cell metabolism · 2014Article
- Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).Molecular neurodegeneration · 2014Article
- Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.Cell death and differentiation · 2013Article
- Article
- Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase.Journal of molecular neuroscience : MN · 2012Article
- Regulation of parkin and PINK1 by neddylation.Human molecular genetics · 2012Article
- Oxidative stress in genetic mouse models of Parkinson's disease.Oxidative medicine and cellular longevity · 2012Review
- Probing mechanisms that underlie human neurodegenerative diseases in Drosophila.Annual review of genetics · 2012Review
- Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.PLoS genetics · 2012Article
- RNAi screening: new approaches, understandings, and organisms.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMutations in parkin and PTEN-induced kinase 1 (Pink1) lead to autosomal recessive forms of Parkinson's disease (PD). parkin and Pink1 encode a ubiquitin-protein ligase and a mitochondrially localized serine/threonine kinase, respectively. Recent studies have implicated Parkin and Pink1 in a common and evolutionarily conserved pathway for protecting mitochondrial integrity.
resultsTo systematically identify novel components of the PD pathways, we generated a genetic background that allowed us to perform a genome-wide F1 screen for modifiers of Drosophila parkin (park) and Pink1 mutant phenotype. From screening ~80% of the fly genome, we identified a number of cytological regions that interact with park and/or Pink1. Among them, four cytological regions were selected for identifying corresponding PD-interacting genes. By analyzing smaller deficiency chromosomes, available transgenic RNAi lines, and P-element insertions, we identified five PD-interacting genes. Among them, opa1 and drp1 have been previously implicated in the PD pathways, whereas debra (dbr), Pi3K21B and β4GalNAcTA are novel PD-interacting genes.
conclusionsWe took an unbiased genetic approach to systematically isolate modifiers of PD genes in Drosophila. Further study of novel PD-interacting genes will shed new light on the function of PD genes and help in the development of new therapeutic strategies for treating Parkinson's disease.
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