ArticleBMC pulmonary medicine2011
Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction.
Article in BMC pulmonary medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity.European journal of medical research · 2023Observational
- Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis.International journal of molecular sciences · 2020Review
- The Lung Mucosa Environment in the Elderly Increases Host Susceptibility to Mycobacterium tuberculosis Infection.The Journal of infectious diseases · 2019Article
- Damage-Associated Molecular Patterns and Myeloid-Derived Suppressor Cells in Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease Patients.Journal of immunology research · 2019Article
- Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking.PloS one · 2019Article
- Surfactant Protein D in Respiratory and Non-Respiratory Diseases.Frontiers in medicine · 2018Review
- The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma.International journal of molecular sciences · 2017Review
- Ion channels of the lung and their role in disease pathogenesis.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Peroxisome proliferator-activated receptor-γ in induced sputum is correlated with MMP-9/TIMP-1 imbalance and formation of emphysema in COPD patients.Journal of thoracic disease · 2017Article
- Surfactant protein D, a clinical biomarker for chronic obstructive pulmonary disease with excellent discriminant values.Experimental and therapeutic medicine · 2016Article
- Serum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE).PloS one · 2016Article
- Relationships of MMP-9 and TIMP-1 proteins with chronic obstructive pulmonary disease risk: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- Polysaccharide Extracted from Laminaria japonica Delays Intrinsic Skin Aging in Mice.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- What do changes in concentrations of serum surfactant proteins A and D in OSA mean?Sleep & breathing = Schlaf & Atmung · 2015Article
- Serum metalloproteinase-9 is related to COPD severity and symptoms - cross-sectional data from a population based cohort-study.Respiratory research · 2015Article
- FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure.Respiratory research · 2014Article
- Article
- Factors influencing the measurement of plasma/serum surfactant protein D levels by ELISA.PloS one · 2014Article
- Associations of smoking status and serious psychological distress with chronic obstructive pulmonary disease.International journal of high risk behaviors & addiction · 2013Article
- Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD.Mediators of inflammation · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA significant number of young people start smoking at an age of 13-15, which means that serious smoking-evoked changes may have been occurred by their twenties. Surfactant proteins (SP) and matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been linked to cigarette smoke induced lung remodelling and chronic obstructive pulmonary disease (COPD). However, the level of these proteins has not been examined during ageing or in young individuals with short smoking histories.
methodsPlasma levels of SP-A, SP-D, MMP-9, and TIMP-1 were measured by EIA/ELISA from young (18-23 years) non-smoking controls (YNS) (n = 36), smokers (YS) (n = 51), middle aged/elderly (37-77 years) non-smoking controls (ONS) (n = 40), smokers (OS) (n = 64) (FEV1/FVC >0.7 in all subjects) and patients with COPD (n = 44, 35-79 years).
resultsPlasma levels of SP-A increased with age and in the older group in relation to smoking and COPD. Plasma SP-D and MMP-9 levels did not change with age but were elevated in OS and COPD as compared to ONS. The TIMP-1 level declined with age but increased in chronic smokers when compared to ONS. The clearest correlations could be detected between plasma SP-A vs. age, pack years and FEV1/FVC. The receiver operating characteristic (ROC) curve analysis revealed SP-A to be the best marker for discriminating between patients with COPD and the controls (area under ROC curve of 0.842; 95% confidence interval, 0.785-0.899; p < 0.001).
conclusionsAge has a significant contribution to potential markers related to smoking and COPD; SP-A seems to be the best factor in differentiating COPD from the controls.
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