ArticleEvoDevo2011
Involvement of the conserved Hox gene Antennapedia in the development and evolution of a novel trait.
Article in EvoDevo, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
- Genetics of butterfly eyespot plasticity.Nature ecology & evolution · 2025Article
- Wound-induced eyespots on butterfly wings at the intersection of immune response and pigmentation development.BMC biology · 2025Article
- Turning lances into shields: flower mantids stretch their raptorial forelegs to avert and deflect predator attack.Proceedings. Biological sciences · 2025Article
- CRISPR/Cas9-Mediated Mutagenesis ofInsects · 2023Article
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- Article
- Butterfly eyespots evolved via cooption of an ancestral gene-regulatory network that also patterns antennae, legs, and wings.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Rapid radiation in a highly diverse marine environment.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Stage- and sex-specific transcriptome analyses reveal distinctive sensory gene expression patterns in a butterfly.BMC genomics · 2021Article
- AInternational journal of molecular sciences · 2021Article
- Hox dosage contributes to flight appendage morphology in Drosophila.Nature communications · 2021Article
- Hox genes are essential for the development of eyespots in Bicyclus anynana butterflies.Genetics · 2021Article
- Wing serial homologues and the diversification of insect outgrowths: insights from the pupae of scarab beetles.Proceedings. Biological sciences · 2021Article
- Article
- Dissection of Larval and Pupal Wings ofMethods and protocols · 2020Article
- Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process.Development (Cambridge, England) · 2019Article
- Conservation and flexibility in the gene regulatory landscape of heliconiine butterfly wings.EvoDevo · 2019Article
- The mimetic wing pattern ofCommunications biology · 2019Article
- A new A-P compartment boundary and organizer in holometabolous insect wings.Scientific reports · 2017Article
- Wound healing, calcium signaling, and other novel pathways are associated with the formation of butterfly eyespots.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHox proteins specify segment identity during embryogenesis and have typical associated expression patterns. Changes in embryonic expression and activity of Hox genes were crucial in the evolution of animal body plans, but their role in the post-embryonic development of lineage-specific traits remains largely unexplored. Here, we focus on the insect Hox genes Ultrabithorax (Ubx) and Antennapedia (Antp), and implicate the latter in the formation and diversification of novel, butterfly-specific wing patterns.
resultsFirst, we describe a conserved pattern of Ubx expression and a novel pattern of Antp expression in wing discs of Bicyclus anynana butterflies. The discrete, reiterated domains of Antp contrast with the typical expression of Hox genes in single continuous regions in arthropod embryos. Second, we show that this pattern is associated with the establishment of the organizing centres of eyespots. Antp upregulation is the earliest event in organizer development described to date, and in contrast to all genes implicated in eyespot formation, is exclusive to those centres. Third, our comparative analysis of gene expression across nymphalids reveals unexpected differences in organizer determination.
conclusionsWe show that the Antp's recruitment for the formation of novel traits in butterfly wing discs involved the evolution of new expression domains, and is restricted to a particular lineage. This study contributes novel insights into the evolution of Antp expression, as well as into the genetic mechanisms underlying morphological diversification. Our results also underscore how a wider representation of morphological and phylogenetic diversity is essential in evolutionary developmental biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.