ArticleDigestive diseases and sciences2011
Serum vitamin D concentrations and unexplained elevation in ALT among US adults.
Article in Digestive diseases and sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 73 citations in OpenAlex.
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- Article
- Vitamin D Sufficiency Revisited: Evidence of a Dose-Response Effect for MASLD in Adults at Risk.Nutrients · 2026Article
- Consequences of vitamin D deficiency or overdosage on follicular development and steroidogenesis in Normo and hypo calcemic mouse models.Scientific reports · 2025Article
- Development and validation of an explainable machine learning model for predicting osteoporosis in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Relationship between non-alcoholic fatty liver and progressive fibrosis and serum 25-hydroxy vitamin D in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2024Article
- Vitamin D was Superior to Omega-3 as a Simvastatin Adjuvant in Improving Blood Lipids and Atherogenic Index in Type-I Dyslipidemic Rats.Turkish journal of pharmaceutical sciences · 2024Article
- High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial.Journal of health, population, and nutrition · 2023Article
- Nonalcoholic Fatty Liver Disease and Endocrine Axes-A Scoping Review.Metabolites · 2022Article
- The Interplay of Vitamin D Deficiency and Cellular Senescence in The Pathogenesis of Obesity-Related Co-Morbidities.Nutrients · 2021Review
- Review
- Inverse Association between Serum 25-hydroxyvitamin D Levels and Risk of Suspected Non-Alcoholic Fatty Liver Disease in Obese Population.International journal of environmental research and public health · 2021Article
- Efficacy of vitamin D supplementation on adult patients with non-alcoholic fatty liver disease: a single-center experience.Gastroenterology and hepatology from bed to bench · 2021Article
- The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Article
- Association Between Vitamin D Deficiency and Suspected Nonalcoholic Fatty Liver Disease in an Adolescent Population.Pediatric gastroenterology, hepatology & nutrition · 2019Article
- The Association of leptin with severity of non-alcoholic fatty liver disease: A population-based study.Clinical and molecular hepatology · 2018Article
- Vitamin D and the Liver-Correlation or Cause?Nutrients · 2018Review
- Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data.World journal of hepatology · 2018Article
- Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2018Review
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2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLow serum levels of vitamin D are associated with metabolic syndrome. Participants in NHANES III with unexplained elevation in ALT levels have high prevalence of metabolic syndrome. We hypothesized that the serum concentrations of vitamin D were inversely associated with unexplained elevation in ALT.
methodsA total of 6,826 fasting subjects underwent morning physical examination and met the inclusion and exclusion criteria. From these participants, we have constructed cases with unexplained elevation in ALT (n = 308) and compared their serum vitamin D concentrations to matched controls with normal ALT (N = 979). We examined the prevalence of unexplained elevation in ALT level across different quartiles of vitamin D levels.
resultsParticipants with unexplained elevation in ALT had significantly lower serum vitamin D levels compared to controls (61.8 ± 26.0 nmol/l vs. 66.8 ± 27.1 nmol/l, P < 0.01). The unadjusted prevalence of unexplained elevation in ALT in patients with highest to lowest quartiles of serum vitamin D levels were 21.4, 21.4, 25.6, and 31.5%, respectively. Compared to lowest quartile, patients with top two quartiles of serum vitamin D levels had significantly lower prevalence of unexplained elevation in ALT (OR, 95% CI for highest quartile 0.62 [0.43-0.89] and for third quartile 0.61 [0.42-0.86]). This relationship persisted even after controlling for metabolic syndrome, insulin resistance, and serum triglycerides.
conclusionsThis study suggests a significant inverse relationship between serum vitamin D levels and unexplained elevation in ALT. Further studies are needed to confirm this observation and to understand the basis for and implications of this observation.
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