ArticleNeurochemical research2011
Effect of long-term normobaric hyperoxia on oxidative stress in mitochondria of the guinea pig brain.
Article in Neurochemical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Adjuvant High-Flow Normobaric Oxygen After Mechanical Thrombectomy for Anterior Circulation Stroke: a Randomized Clinical Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Trial
- Dynamics in Redox-Active Molecules Following Ischemic Preconditioning in the Brain.Neurology international · 2024Article
- Oxygen toxicity: cellular mechanisms in normobaric hyperoxia.Cell biology and toxicology · 2023Review
- Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes.CNS neuroscience & therapeutics · 2022Article
- Partially ionized medical oxygen as a supplementary treatment for COVID-19.Wiener klinische Wochenschrift · 2020Article
- COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.GeroScience · 2020Review
- Dynamic oxygen changes during status epilepticus and subsequent endogenous kindling.Epilepsia · 2020Article
- Autonomic and Cognitive Function Response to Normobaric Hyperoxia Exposure in Healthy Subjects. Preliminary Study.Medicina (Kaunas, Lithuania) · 2020Article
- Proteomic analysis of mitochondrial proteins in the guinea pig heart following long-term normobaric hyperoxia.Molecular and cellular biochemistry · 2017Article
- Comparative Response of Brain to Chronic Hypoxia and Hyperoxia.International journal of molecular sciences · 2017Review
- Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature.Medical gas research · 2015Article
- Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
- Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide.Journal of neuro-oncology · 2012Article
- Intracellular signaling MAPK pathway after cerebral ischemia-reperfusion injury.Neurochemical research · 2012Article
- Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective.Medical gas researchReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normobaric hyperoxia (NBO) is applied for treatment of various clinical conditions related to hypoxia, but it can potentially also induce generation of reactive oxygen species, causing cellular damage. In this study, we examined the effects of 60 h NBO treatment on lipid and protein oxidative damage and activity of superoxide dismutase (Mn-SOD) in brain mitochondria of guinea pigs. Despite significant stimulation of Mn-SOD expression and activity the NBO treatment resulted in accumulation of markers of oxidative lesions, including lipid peroxidation (conjugated dienes, thiobarbituric acid reactive substances) and protein modification (bityrosines, adducts with lipid peroxidation products, oxidized thiols). When inhaled O(2) was enriched with oxygen cation, O (2) (•+) , the Mn-SOD expression and activity were stimulated to similar extend, but lipid peroxidation and protein oxidation were prevented. These results suggest that long-term NBO treatment causes oxidative stress, but enrichment of inhaled oxygen by oxygen cation can protect the brain again adverse effects of hyperoxia.
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