ArticleParasitology research2011
An evolutionary analysis of trypanosomatid GP63 proteases.
Article in Parasitology research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Exploring the genomic landscape of the GP63 family in Trypanosoma cruzi: Evolutionary dynamics and functional peculiarities.PLoS neglected tropical diseases · 2025Article
- Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor.PLoS neglected tropical diseases · 2021Article
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- Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.PLoS neglected tropical diseases · 2015Article
- Genome evolution in trypanosomatid parasites.Parasitology · 2015Review
- The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite.Evolutionary bioinformatics online · 2014Article
- Mitogen-activated protein kinases in innate immunity.Nature reviews. Immunology · 2013Review
- Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms.Parasitology research · 2012Article
- Impact of Leishmania metalloprotease GP63 on macrophage signaling.Frontiers in cellular and infection microbiology · 2012Review
- Host-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Journal of parasitology research · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The trypanosomatid GP63 proteases are known to be involved in parasite-host interaction and exhibit strong sequence and structural similarities to those of their hosts and insect vectors. Based on genome sequences of the three trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., we annotated all their GP63 proteases and divided highly duplicated T. cruzi GP63 proteases into four novel groups according to sequence features. In Leishmania spp., we studied the evolutionary dynamics of GP63 proteins and identified 57 amino acid sites that are under significant positive selections. These sites may contribute to the functional variations of the GP63 proteases and provide clues for vaccine development.
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