ArticlePsychopharmacology2011
Acute nicotine increases both impulsive choice and behavioural disinhibition in rats.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Effect of varenicline on aspects of inhibitory control in smokers.Psychopharmacology · 2014Trial
- Dissociable roles of dopamine D1 and nicotinic receptors in nicotine-motivated responding and impulsive action in a Go/No-Go self-administration task.bioRxiv : the preprint server for biology · 2026Article
- Differential effects of nAChR modulators on impulsive action in a nicotine self-administration Go/No-Go task in rats.Frontiers in pharmacology · 2026Article
- Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans.PLoS biology · 2024Article
- Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice.Scientific reports · 2024Article
- p-Nrf2/HO-1 Pathway Involved in Methamphetamine-induced Executive Dysfunction through Endoplasmic Reticulum Stress and Apoptosis in the Dorsal Striatum.Neurotoxicity research · 2023Article
- Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice.bioRxiv : the preprint server for biology · 2023Article
- Acetylcholine deficit causes dysfunctional inhibitory control in an aging-dependent manner.Scientific reports · 2022Article
- The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.Brain sciences · 2022Review
- Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders.Frontiers in behavioral neuroscience · 2021Review
- Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats.Journal of psychopharmacology (Oxford, England) · 2020Article
- Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research.Frontiers in pharmacology · 2020Article
- The neurobiology of impulsivity and substance use disorders: implications for treatment.Annals of the New York Academy of Sciences · 2019Review
- Impact of Substance Use Disorder Pharmacotherapy on Executive Function: A Narrative Review.Frontiers in psychiatry · 2019Review
- Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Reduction in delay discounting due to nicotine and its attenuation by cholinergic antagonists in Lewis and Fischer 344 rats.Psychopharmacology · 2018Article
- Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists.Psychopharmacology · 2016Article
- Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.Nature neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleHeavy smokers exhibit greater levels of impulsive choice and behavioural disinhibition than non-smokers. To date, however, the relationship between nicotine use and differing dimensions of impulsivity has not been systematically assessed.
objectivesA series of studies was designed to assess the acute dose-response effects of nicotine and the nicotinic receptor antagonist mecamylamine alone, and in combination with nicotine, on impulsive choice and behavioural disinhibition in rats.
methodsSeparate groups of rats were trained on a symmetrically reinforced go/no-go task to measure levels of disinhibition and a systematic delayed reward task to measure levels of impulsive choice. Once trained, all animals in each task were treated acutely with nicotine (0.125, 0.25, 0.5 and 1.0 mg/kg), mecamylamine (0.1, 0.3 and 1.0 mg/kg) and varying doses of mecamylamine (0.1, 0.3 and 1.0 mg/kg) prior to nicotine (0.5 mg/kg). An additional experiment assessed the effects of alterations in primary motivation (presatiation and fasting) on performance in both tasks.
resultsAcute nicotine increased both impulsive choice and behavioural disinhibition, effects that were blocked by pre-treatment with mecamylamine. Mecamylamine when administered alone did not alter impulsive behaviour. The lack of effect of presatiation on performance measures suggests that the observed nicotine-induced impulsivity cannot be attributed to the anorectic activity of the compound.
conclusionsPresent findings support the hypothesis that heightened impulsivity in smokers may in part be a consequence of the direct acute effects of nicotine. As such, drug-induced changes in impulsivity may play a critical role in the transition to and maintenance of nicotine dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.