Trial reportPsychopharmacology2011
Alcohol dose effects on stress response to cued threat vary by threat intensity.
Trial report in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05692830 (Towards a Wearable Alcohol Biosensor), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms
Who cites it
11 citing papers in PubMed.
- Alcohol stress response dampening: selective reduction of anxiety in the face of uncertain threat.Journal of psychopharmacology (Oxford, England) · 2012Trial
- Moderation effects of health behaviors on stress and suicidal ideation in adolescents: a cross-sectional survey during COVID-19.Scientific reports · 2023Article
- Alcohol's effects during uncertain and uncontrollable stressors in the laboratory.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Psychometric qualities of the English Coping Scales of the Stress and Coping Inventory in a representative UK sample.BMC psychology · 2021Article
- Stress Allostasis in Substance Use Disorders: Promise, Progress, and Emerging Priorities in Clinical Research.Annual review of clinical psychology · 2020Review
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- Tension reduction and affect regulation: An examination of mood indices on drinking and non-drinking days among university student drinkers.Experimental and clinical psychopharmacology · 2018Article
- Effect of alcohol dose on deliberate self-harm in men and women.Journal of consulting and clinical psychology · 2017Article
- Increased startle potentiation to unpredictable stressors in alcohol dependence: Possible stress neuroadaptation in humans.Journal of abnormal psychology · 2017Article
- Altered subjective reward valuation among female heavy marijuana users.Experimental and clinical psychopharmacology · 2017Article
- How bad could it be? Alcohol dampens stress responses to threat of uncertain intensity.Psychological science · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
rationaleClarification of alcohol's effect on stress response during threat is critical to understand motivation for alcohol use and related alcohol-use disorders. Evaluation of stress response dampening (SRD) effects of alcohol has been limited by nonsystematic use of varied experimental methods and measures.
objectivesThis experiment parametrically varied alcohol dose and shock threat intensity among social drinkers to examine their effects on startle potentiation, a physiological measure of the affective component of the stress response.
methodsNinety-six participants were assigned to one of four beverage groups: placebo and target blood alcohol concentration (BAC) groups of 0.04%, 0.075%, and 0.11%. Participants viewed colored cues presented in shock and no-shock blocks. Distinct colored cues predicted imminent low, moderate, or high intensity electric shock administration. Startle potentiation during shock threat relative to no-shock cues indexed affective response.
resultsHigh threat increased startle potentiation relative to moderate/low intensity threat. Startle potentiation decreased as BAC increased. Threat intensity moderated this BAC effect with the strongest BAC effect observed during high threat. Analysis of individual difference moderators revealed reduced effect of BAC among heavier, more problematic drinkers.
conclusionsClear alcohol SRD effects were observed. These SRD effects were greatest at higher BACs and during more potent threat. Failure to account for these factors may partially explain inconsistent findings in past laboratory SRD research. Furthermore, they suggest greater reinforcement from alcohol at higher doses and among individuals with greater stress. Moderation of SRD effects by alcohol consumption and problems point to possible important risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.