ArticlePhysical chemistry chemical physics : PCCP2011
Reconstructing protein remodeled membranes in molecular detail from mesoscopic models.
Article in Physical chemistry chemical physics : PCCP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Progressive Backmapping of Highly Coarse-Grained Protein Models.bioRxiv : the preprint server for biology · 2026Article
- Modeling membrane reshaping driven by dynamic protein assemblies.Current opinion in structural biology · 2023Review
- Bottom-up Coarse-Graining: Principles and Perspectives.Journal of chemical theory and computation · 2022Review
- Backmapping triangulated surfaces to coarse-grained membrane models.Nature communications · 2020Article
- Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Systems biology of cellular membranes: a convergence with biophysics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- The mesoscopic membrane with proteins (MesM-P) model.The Journal of chemical physics · 2017Article
- Multiscale simulations of protein-facilitated membrane remodeling.Journal of structural biology · 2016Review
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins.Physics reports · 2014Article
- Protein-mediated transformation of lipid vesicles into tubular networks.Biophysical journal · 2013Article
- A comparison of coarse-grained and continuum models for membrane bending in lipid bilayer fusion pores.Biophysical journal · 2013Article
- Understanding the role of amphipathic helices in N-BAR domain driven membrane remodeling.Biophysical journal · 2013Article
- Membrane sculpting by F-BAR domains studied by molecular dynamics simulations.PLoS computational biology · 2013Article
- Curvature forces in membrane lipid-protein interactions.Biochemistry · 2012Article
- Membrane binding and self-association of the epsin N-terminal homology domain.Journal of molecular biology · 2012Article
- Phenomenology based multiscale models as tools to understand cell membrane and organelle morphologies.Advances in planar lipid bilayers and liposomesArticle
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3 authors.
Funding
Abstract
We present a method for "inverse coarse graining," rebuilding a higher resolution model from a lower resolution one, in order to rebuild protein coats for remodeled membranes of complex topology. The specific case of membrane remodeling by N-BAR domain containing proteins is considered here, although the overall method is general and thus applicable to other membrane remodeling phenomena. Our approach begins with a previously developed, discretized mesoscopic continuum membrane model (EM2) which has been shown to capture the reticulated membrane topologies often observed for N-BAR/liposome systems by electron microscopy (EM). The information in the EM2 model-directions of the local curvatures and a low resolution sample of the membrane surface-is then used to construct a coarse-grained (CG) system with one site per lipid and 26 sites per protein. We demonstrate the approach on pieces of EM2 structures with three different topologies that have been observed by EM: A tubule, a "Y" junction, and a torus. We show that the approach leads to structures that are stable under subsequent constant temperature CG simulation, and end by considering the future application of the methodology as a hybrid approach that combines experimental information with computer modeling.
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