ArticleFrontiers in systems neuroscience2011
Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K
Article in Frontiers in systems neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- The graded effect of propofol in electrophysiology-guided navigation during deep brain stimulation surgery.NPJ Parkinson's disease · 2026Article
- Hydrogen peroxide suppresses excitability of gonadotropin-releasing hormone neurons in adult mouse.Frontiers in endocrinology · 2022Article
- Hydrogen Peroxide Gates a Voltage-Dependent Cation Current inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Article
- Article
- Hydrogen peroxide modulates synaptic transmission in ventral horn neurons of the rat spinal cord.The Journal of physiology · 2016Article
- ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.Ageing research reviews · 2015Review
- Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward.Nature communications · 2015Article
- Inhibitory and excitatory neuromodulation by hydrogen peroxide: translating energetics to information.The Journal of physiology · 2015Review
- Bursting activity of substantia nigra pars reticulata neurons in mouse parkinsonism in awake and anesthetized states.Neurobiology of disease · 2015Article
- Quantitation of hydrogen peroxide fluctuations and their modulation of dopamine dynamics in the rat dorsal striatum using fast-scan cyclic voltammetry.ACS chemical neuroscience · 2013Article
- Flufenamic acid as an ion channel modulator.Pharmacology & therapeutics · 2013Review
- TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Classification of H₂O₂as a neuromodulator that regulates striatal dopamine release on a subsecond time scale.ACS chemical neuroscience · 2012Review
- Intrinsic and integrative properties of substantia nigra pars reticulata neurons.Neuroscience · 2011Review
- H2O2: a dynamic neuromodulator.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Substantia nigra pars reticulata (SNr) GABAergic neurons are key output neurons of the basal ganglia. Given the role of these neurons in motor control, it is important to understand factors that regulate their firing rate and pattern. One potential regulator is hydrogen peroxide (H₂O₂), a reactive oxygen species that is increasingly recognized as a neuromodulator. We used whole-cell current clamp recordings of SNr GABAergic neurons in guinea-pig midbrain slices to determine how H₂O₂ affects the activity of these neurons and to explore the classes of ion channels underlying those effects. Elevation of H₂O₂ levels caused an increase in the spontaneous firing rate of SNr GABAergic neurons, whether by application of exogenous H₂O₂ or amplification of endogenous H₂O₂ through inhibition of glutathione peroxidase with mercaptosuccinate. This effect was reversed by flufenamic acid (FFA), implicating transient receptor potential (TRP) channels. Conversely, depletion of endogenous H₂O₂ by catalase, a peroxidase enzyme, decreased spontaneous firing rate and firing precision of SNr neurons, demonstrating tonic control of firing rate by H₂O₂. Elevation of H₂O₂ in the presence of FFA revealed an inhibition of tonic firing that was prevented by blockade of ATP-sensitive K(+) (K(ATP)) channels with glibenclamide. In contrast to guinea-pig SNr neurons, the dominant effect of H₂O₂ elevation in mouse SNr GABAergic neurons was hyperpolarization, indicating a species difference in H₂O₂-dependent regulation. Thus, H₂O₂ is an endogenous modulator of SNr GABAergic neurons, acting primarily through presumed TRP channels in guinea-pig SNr, with additional modulation via K(ATP) channels to regulate SNr output.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.