ArticleFrontiers in neuroanatomy2011
Topographical organization of the pedunculopontine nucleus.
Article in Frontiers in neuroanatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
122 citing papers in PubMed, 3 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings.Journal of neurology · 2024Pooled it
- The neuroanatomy of developmental language disorder: a systematic review and meta-analysis.Nature human behaviour · 2024Pooled it
- Clinical Effectiveness of Muscarinic Receptor-Targeted Interventions in Neuropsychiatric Disorders: A Systematic Review.CNS drugs · 2022Pooled it
- Low-frequency subthalamic nucleus deep brain stimulation for axial symptoms in advanced Parkinson's disease.Journal of neurology · 2013Trial
- A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation.Brain : a journal of neurology · 2012Trial
- The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson's disease male mice.NPJ Parkinson's disease · 2026Article
- The central cholinergic system as a therapeutic target in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease.Brain pathology (Zurich, Switzerland) · 2025Article
- Article
- Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.Brain : a journal of neurology · 2025Review
- The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- A Computational Model for the Simulation of Prepulse Inhibition and Its Modulation by Cortical and Subcortical Units.Brain sciences · 2024Article
- The Basal Ganglia and Mesencephalic Locomotor Region Connectivity Matrix.Current neuropharmacology · 2024Review
- How deep is the brain? The shallow brain hypothesis.Nature reviews. Neuroscience · 2023Review
- Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease.Translational neurodegeneration · 2023Review
- Mitochondrial dysfunction in Parkinson's disease - a key disease hallmark with therapeutic potential.Molecular neurodegeneration · 2023Review
- Echoes from Intrinsic Connectivity Networks in the Subcortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Pedunculopontine Chx10Nature neuroscience · 2023Article
- Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder.NPJ Parkinson's disease · 2023Article
- Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury.Cell reports. Medicine · 2023Article
62 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neurons in the pedunculopontine nucleus (PPN) exhibit a wide heterogeneity in terms of their neurochemical nature, their discharge properties, and their connectivity. Such characteristics are reflected in their functional properties and the behaviors in which they are involved, ranging from motor to cognitive functions, and the regulation of brain states. A clue to understand this functional versatility arises from the internal organization of the PPN. Thus, two main areas of the PPN have been described, the rostral and the caudal, which display remarkable differences in terms of the distribution of neurons with similar phenotype and the projections that originate from them. Here we review these differences with the premise that in order to understand the function of the PPN it is necessary to understand its intricate connectivity. We support the case that the PPN should not be considered as a homogeneous structure and conclude that the differences between rostral and caudal PPN, along with their intrinsic connectivity, may underlie the basis of its complexity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.