ArticleFrontiers in integrative neuroscience2011
Amygdala stimulation evokes time-varying synaptic responses in the gustatory cortex of anesthetized rats.
Article in Frontiers in integrative neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Sensory and palatability coding of taste stimuli in cortex involves dynamic and asymmetric cortico-amygdalar interactions.Journal of neurophysiology · 2026Article
- Article
- Valence Encoding Signals in the Human Amygdala and the Willingness to Eat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior.Frontiers in molecular neuroscience · 2019Article
- Fifty shades of inhibition.Current opinion in neurobiology · 2017Review
- The Insula and Taste Learning.Frontiers in molecular neuroscience · 2017Review
- AmyloidInternational journal of peptides · 2017Article
- Article
- A gustocentric perspective to understanding primary sensory cortices.Current opinion in neurobiology · 2016Review
- Laminar- and Target-Specific Amygdalar Inputs in Rat Primary Gustatory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Extensive lesions in rat insular cortex significantly disrupt taste sensitivity to NaCl and KCl and slow salt discrimination learning.PloS one · 2015Article
- Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Thalamic contribution to cortical processing of taste and expectation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neural processing of gustatory information in insular circuits.Current opinion in neurobiology · 2012Review
- Inactivation of basolateral amygdala specifically eliminates palatability-related information in cortical sensory responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gustatory stimuli are characterized by a specific hedonic value; they are either palatable or aversive. Hedonic value, along with other psychological dimensions of tastes, is coded in the time-course of gustatory cortex (GC) neural responses and appears to emerge via top-down modulation by the basolateral amygdala (BLA). While the importance of BLA in modulating gustatory cortical function has been well established, the nature of its input onto GC neurons is largely unknown. Somewhat conflicting results from extracellular recordings point to either excitatory or inhibitory effects. Here, we directly test the hypothesis that BLA can evoke time-varying - excitatory and inhibitory - synaptic responses in GC using in vivo intracellular recording techniques in urethane anesthetized rats. Electrical stimulation of BLA evoked a post-synaptic potential (PSP) in GC neurons that resulted from a combination of short and long latency components: an initial monosynaptic, glutamatergic potential followed by a multisynaptic, GABAergic hyperpolarization. As predicted by the dynamic nature of amygdala evoked potentials, trains of five BLA stimuli at rates that mimic physiological firing rates (5-40 Hz) evoke a combination of excitation and inhibition in GC cells. The magnitude of the different components varies depending on the frequency of stimulation, with summation of excitatory and inhibitory inputs reaching its maximum at higher frequencies. These experiments provide the first description of BLA synaptic inputs to GC and reveal that amygdalar afferents can modulate gustatory cortical network activity and its processing of sensory information via time-varying synaptic dynamics.
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