An unexpected role for MHC class II.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88.PloS one · 2012
   Trial
2. Molecular and Cellular Mechanisms Influenced by Postbiotics.International journal of molecular sciences · 2021
   Review
3. MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity.Immunologic research · 2021
   Review
4. Hyperglycemia and dyslipidemia: Reduced HLA-DR expression in monocyte subpopulations from diabetes patients.Human immunology · 2021
   Observational
5. HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2018
   Article
6. Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling.Scientific reports · 2018
   Article
7. Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity.Seminars in immunopathology · 2015
   Review
8. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen.Scientific reports · 2015
   Article
9. New frontiers for platelet CD154.Experimental hematology & oncology · 2015
   Article
10. Highlights of the advances in basic immunology in 2011.Cellular & molecular immunology · 2012
    Review
11. Intracellular nucleic acid sensors and autoimmunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011
    Review
12. A small molecule that mimics the BB-loop in the Toll interleukin-1 (IL-1) receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice.The Journal of biological chemistry · 2011
    Article
13. Regulation of the Late Onset alzheimer's Disease AssociatedAmerican journal of Alzheimer's disease and other dementias
    Article

Corrections and comments

• Comment on
  Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk.2011

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as