ReviewCurrent opinion in HIV and AIDS2011
Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses.
Review in Current opinion in HIV and AIDS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Safety, tolerability, and immunogenicity of repeated doses of dermavir, a candidate therapeutic HIV vaccine, in HIV-infected patients receiving combination antiretroviral therapy: results of the ACTG 5176 trial.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- Acute-phase innate immune responses in SIVmac239-infectedFrontiers in immunology · 2024Article
- Programming cytomegalovirus as an HIV vaccine.Trends in immunology · 2023Review
- Editorial: Preclinical macaque models of viral diseases.Frontiers in immunology · 2023Article
- How elite controllers and posttreatment controllers inform our search for an HIV-1 cure.The Journal of clinical investigation · 2021Review
- Isolation of a monoclonal antibody from a phage display library binding the rhesus macaque MHC class I allomorph Mamu-A1*001.PloS one · 2017Article
- Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining.Journal of visualized experiments : JoVE · 2016Article
- Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection.The Journal of general virology · 2016Article
- Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection.Journal of virology · 2015Article
- B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.Nature medicine · 2015Article
- In silico design of a DNA-based HIV-1 multi-epitope vaccine for Chinese populations.Human vaccines & immunotherapeutics · 2015Article
- HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice.Journal of virology · 2014Article
- Nonhuman primate models in AIDS research.Current opinion in HIV and AIDS · 2013Review
- The implications of viral reservoirs on the elite control of HIV-1 infection.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs.Nature communications · 2012Article
- Relevance of long-lived CD8(+) T effector memory cells for protective immunity elicited by heterologous prime-boost vaccination.Frontiers in immunology · 2012Article
- HIV controllers: a multifactorial phenotype of spontaneous viral suppression.Clinical immunology (Orlando, Fla.) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewWe will summarize recent advances in research regarding control of simian immunodeficiency virus replication in nonhuman primate models. We will then relate these findings to the broader field of human immunodeficiency virus (HIV) vaccine development. RECENT
findingsRecent studies have highlighted the importance of T-cell responses in elite control, especially CD8+ T-cell responses and provide insight into the kinetics and qualities of such effective responses. Additionally, these findings suggest that the peptides bound by elite control-associated major histocompatibility complex class I molecules in monkeys and humans share many properties. SUMMARY: Animal models of effective immune control of immunodeficiency virus replication have provided important insight into the components of successful immune responses against these viruses. Similarities between the human and nonhuman primate responses to immunodeficiency viruses should help us understand the nature of elite control. Further study of the acute phase, in which virus replication is first brought under control, may help define important characteristics of viral control that could be engendered by a successful HIV vaccine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.