ArticleCell cycle (Georgetown, Tex.)2011
Role of STRAP in regulating GSK3β function and Notch3 stabilization.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer.Journal of experimental & clinical cancer research : CR · 2026Article
- The Role of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Signaling in Cancer.Cells · 2025Review
- STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.Virology journal · 2024Article
- Article
- Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance.International journal of molecular sciences · 2022Review
- Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK).Journal of pediatric surgery · 2022Article
- Article
- SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability.International journal of molecular sciences · 2020Article
- Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance.Translational psychiatry · 2019Article
- Tumor-suppressive or tumor-supportive: For p53, that is the question.Molecular & cellular oncology · 2018Article
- Strap associates with Csde1 and affects expression of select Csde1-bound transcripts.PloS one · 2018Article
- The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.The EMBO journal · 2017Article
- STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway.Scientific reports · 2016Article
- Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.Oncotarget · 2016Article
- Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.Pharmacology & therapeutics · 2015Review
- GSK-3 as potential target for therapeutic intervention in cancer.Oncotarget · 2014Review
- A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways.Cell cycle (Georgetown, Tex.) · 2014Article
- Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1.Cell cycle (Georgetown, Tex.) · 2014Article
- Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation.Cell cycle (Georgetown, Tex.) · 2013Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
Glycogen synthase kinase 3β (GSK3β) can regulate a broad range of cellular processes in a variety of cell types and tissues through its ability to phosphorylate its substrates in a cell- and time-specific manner. Although it is known that Axin and presenilin help to recruit β-catenin/Smad3 and tau protein to GSK3β, respectively, it is not clear how many of the other GSK3β substrates are recruited to it. Here, we have established the binding of GSK3β with a novel scaffold protein, STRAP, through its WD40 domains. In a new finding, we have observed that STRAP, GSK3β and Axin form a ternary complex together. We show for the first time that intracellular fragment of Notch3 (ICN3) binds with GSK3β through the ankyrin repeat domain. This binding between STRAP and GSK3β is reduced by small-molecule inhibitors of GSK3β. Further studies revealed that STRAP also binds ICN3 through the ankyrin repeat region, and this binding is enhanced in a proteasomal inhibition-dependent manner. In vivo ubiquitination studies indicate that STRAP reduces ubiquitination of ICN3, suggesting a role of STRAP in stabilizing ICN3. This is supported by the fact that STRAP and Notch3 are co-upregulated and co-localized in 59% of non-small cell lung cancers, as observed in an immunohistochemical staining of tissue microarrays. These results provide a potential mechanism by which STRAP regulates GSK3β function and Notch3 stabilization and further support the oncogenic functions of STRAP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.