ArticleProceedings of the National Academy of Sciences of the United States of America2011
Defining the origins of Ras/p53-mediated squamous cell carcinoma.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed.
- RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.The New England journal of medicine · 2012Trial
- Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.Science (New York, N.Y.) · 2026Article
- Epithelial-dermal inflammasome crosstalk in cutaneous squamous cell carcinoma.Molecular biology of the cell · 2026Article
- Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice.International journal of molecular sciences · 2026Article
- SOX2 confers tumour permissiveness in a specific skin progenitor population.Nature communications · 2026Article
- Identification, functional insights and therapeutic targeting of EMT tumour states.Nature reviews. Cancer · 2026Review
- Review
- Molecular and cellular dynamics of squamous cell carcinomas across tissues.Genes & development · 2025Review
- Carcinogenesis trajectories.Frontiers in cell and developmental biology · 2025Article
- Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.Science advances · 2024Article
- Ras promotes germline stem cell division in Drosophila ovaries.Stem cell reports · 2024Article
- Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions.The Journal of cell biology · 2024Article
- Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.Nature cell biology · 2024Article
- Conditional Knockout of N-WASP Enhanced the Formation of Keratinizing Squamous Cell Carcinoma Induced by KRasCancers · 2023Article
- Lymph Vessels Associate with Cancer Stem Cells from Initiation to Malignant Stages of Squamous Cell Carcinoma.International journal of molecular sciences · 2023Article
- Advances in cutaneous squamous cell carcinoma.Nature reviews. Cancer · 2023Review
- Article
- Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy.Science advances · 2023Article
- Loss of Epidermal Homeostasis Underlies the Development of Squamous Cell Carcinoma.Stem cell reviews and reports · 2023Review
- RAS oncogene signal strength regulates matrisomal gene expression and tumorigenicity of mouse keratinocytes.Carcinogenesis · 2022Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The precise identity of cancer cells of origin and the molecular events of tumor initiation in epidermal squamous cell carcinoma (SCC) are unknown. Here we show that malignancy potential is related to the developmental capacity of the initiating cancer cell in a genetically defined, intact, and inducible in vivo model. Specifically, these data demonstrate that SCCs can originate from inside the hair follicle stem cell (SC) niche or from immediate progenitors, whereas more developmentally restricted progeny, the transit amplifying (TA) cells, are unable to generate even benign tumors in the same genetic context. Using a temporal model of tumorigenesis in situ, we highlight the phenotypes of cancer progression from the hair follicle SC niche, including hyperplasia, epithelial to mesenchymal transition, and SCC formation. Furthermore, we provide insights into the inability of hair follicle TA cells to respond to tumorigenic stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.