Evidence map›Paper›PMID 21502424›Full record

ArticleAmerican journal of clinical pathology2011

The efficacy of HGAL and LMO2 in the separation of lymphomas derived from small B cells in nodal and extranodal sites, including the bone marrow.

Sheren F Younes, Andrew H Beck, Robert S Ohgami, Izidore S Lossos, Ronald Levy, Roger A Warnke, Yasodha Natkunam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of clinical pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

  1. Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell LymphomaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2023
    Article
  2. Review
  3. Review
  4. The heterogeneity of follicular lymphomas: from early development to transformation.Virchows Archiv : an international journal of pathology · 2016
    Review
  5. Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas.Virchows Archiv : an international journal of pathology · 2015
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sheren F YounesDept of Pathology, Division of Oncology, Stanford University School of Medicine, CA 94305, USA.
Andrew H Beck
Robert S Ohgami
Izidore S Lossos
Ronald Levy
Roger A Warnke
Yasodha Natkunam
Stanford University · USSylvester Comprehensive Cancer Center · US

Funding

TRIGGERING CELL DEATH IN B CELL LYMPHOMAP01CA034233 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W · 1985 to 2010
$19.5M
ANTIIDIOTYPE THERAPY OF HUMAN B CELL MALIGNANCYR37CA033399 · NCI · STANFORD UNIVERSITY · PI LEVY, RONALD · 1988 to 2007
$4.5M
Prognostic Models in Diffuse Large B-Cell LymphomaR01CA122105 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LOSSOS, IZIDORE S · 2007 to 2010
$1.3M
HUMAN ANTITUMOR THERAPY WITH MONOCLONAL ANTIBODIESR01CA033399 · NCI · STANFORD UNIVERSITY · PI LEVY, RONALD · 1985 to 1998
–
NCI NIH HHS CA122105NCI NIH HHS CA33399NCI NIH HHS P01 CA034233NCI NIH HHS P0I CA34233NCI NIH HHS R01 CA122105NCI NIH HHS R37 CA033399
6 · The paper itself

Abstract

We studied the efficacy of 2 germinal center B-cell markers, HGAL and LMO2, in the separation of lymphomas derived from small B cells, particularly follicular lymphoma (FL) and marginal zone lymphoma occurring in nodal, extranodal, splenic, and bone marrow sites using immunohistochemical analysis for CD10, BCL6, BCL2, HGAL, and LMO2. Our results showed that HGAL and LMO2 are sensitive and specific markers for detecting FL in nodal and extranodal sites. In contrast, all markers were down-regulated in FL infiltrates in the bone marrow. CD10 and HGAL were expressed in a subset of FLs in the bone marrow and were highly correlated with each other and with CD21, a marker of follicular dendritic cells. We conclude that HGAL and LMO2 should be considered in immunohistochemical panels used for the routine workup of lymphomas derived from small B cells. In the bone marrow, staining for HGAL or CD10 can be helpful in making a diagnosis of FL, although they are absent in a subset of cases.

Indexed as

Biomarkers, TumorLymphoma, B-Cell, Marginal ZoneLymphoma, FollicularAdaptor Proteins, Signal TransducingB-LymphocytesBone MarrowDNA-Binding ProteinsGene Expression Regulation, NeoplasticGerminal CenterHumansImmunohistochemistryIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsLymph NodesMetalloproteinsMicrofilament ProteinsAdaptor Proteins, Signal TransducingBiomarkers, TumorDNA-Binding ProteinsGCSAM protein, humanIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsLMO2 protein, humanMetalloproteinsMicrofilament ProteinsNeoplasm ProteinsNeprilysinProto-Oncogene Proteins

Identifiers

PMID21502424
PMCPMC4847143
OpenAlexW2105843172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.