ArticleCold Spring Harbor symposia on quantitative biology2010
Nuclear physics: quantitative single-cell approaches to nuclear organization and gene expression.
Article in Cold Spring Harbor symposia on quantitative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Analysis of a detailed multi-stage model of stochastic gene expression using queueing theory and model reduction.Mathematical biosciences · 2024Article
- The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian.Science advances · 2023Article
- The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian.bioRxiv : the preprint server for biology · 2023Article
- Enhancers, gene regulation, and genome organization.Genes & development · 2021Article
- Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with retinoid X receptor.The Journal of biological chemistry · 2020Article
- Global and targeted approaches to single-cell transcriptome characterization.Briefings in functional genomics · 2018Article
- Article
- Imaging Transcription: Past, Present, and Future.Cold Spring Harbor symposia on quantitative biology · 2015Review
- Eukaryotic transcriptional dynamics: from single molecules to cell populations.Nature reviews. Genetics · 2013Review
- Measuring transcription dynamics in living cells using fluctuation analysis.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Complexity of RNA polymerase II elongation dynamics.Biochimica et biophysica acta · 2012Review
- Transcription goes digital.EMBO reports · 2012Review
- What do expression dynamics tell us about the mechanism of transcription?Current opinion in genetics & development · 2011Review
- Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells.Genetics research international · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The internal workings of the nucleus remain a mystery. A list of component parts exists, and in many cases their functional roles are known for events such as transcription, RNA processing, or nuclear export. Some of these components exhibit structural features in the nucleus, regions of concentration or bodies that have given rise to the concept of functional compartmentalization--that there are underlying organizational principles to be described. In contrast, a picture is emerging in which transcription appears to drive the assembly of the functional components required for gene expression, drawing from pools of excess factors. Unifying this seemingly dual nature requires a more rigorous approach, one in which components are tracked in time and space and correlated with onset of specific nuclear functions. In this chapter, we anticipate tools that will address these questions and provide the missing kinetics of nuclear function. These tools are based on analyzing the fluctuations inherent in the weak signals of endogenous nuclear processes and determining values for them. In this way, it will be possible eventually to provide a computational model describing the functional relationships of essential components.
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Registered trials
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