ArticleReproduction (Cambridge, England)2011
A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin.
Article in Reproduction (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species.Frontiers in genome editing · 2026Review
- Mechanical Response of Mouse Cervices Lacking Decorin and Biglycan During Pregnancy.Journal of biomechanical engineering · 2022Article
- Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
- Comprehensive quantitative characterization of the human term amnion proteome.Matrix biology plus · 2021Article
- Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.International journal of molecular sciences · 2021Review
- Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†.Biology of reproduction · 2021Article
- The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero†.Biology of reproduction · 2021Review
- Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Serum Decorin and Biglycan as Potential Biomarkers to Predict PPROM in Early Gestation.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Immunobiology of Cervix Ripening.Frontiers in immunology · 2019Review
- Mouse models of preterm birth: suggested assessment and reporting guidelines.Biology of reproduction · 2018Review
- Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: The role of decorin.Cell adhesion & migration · 2016Review
- Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation.Molecular reproduction and development · 2015Article
- Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.Matrix biology : journal of the International Society for Matrix Biology · 2015Review
- Altered decorin and Smad expression in human fetal membranes in PPROM.Biology of reproduction · 2014Article
- Finding novel molecular connections between developmental processes and disease.PLoS computational biology · 2014Article
- Biglycan and decorin differentially regulate signaling in the fetal membranes.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
- Extracellular matrix dynamics and fetal membrane rupture.Reproductive sciences (Thousand Oaks, Calif.) · 2013Review
- Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition.PloS one · 2012Article
- Can early pregnancy decorin levels be a potential predictor for preterm birth?Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Preterm premature rupture of membranes is responsible for one-third of preterm births. Ehlers-Danlos syndrome (EDS) is associated with preterm premature rupture of membranes in humans. In particular, an EDS variant is caused by a genetic mutation resulting in abnormal secretion of biglycan and decorin, two small leucine-rich proteoglycans highly expressed in reproductive tissues. Because biglycan/decorin null mutant (Bgn(-/-)Dcn(-/-)) mice demonstrate phenotypic changes similar to EDS, we used this model to test whether either biglycan or decorin or both play a role in the attainment of successful term gestation. Wild-type biglycan null mutant, decorin null mutant, and biglycan/decorin null mutant pregnancies were assessed for the length of gestation, pup and placenta weight, and litter size. Quantitative real-time PCR was performed to measure biglycan and decorin gene expression, and immunohistochemistry was performed to assess protein expression in placenta and fetal membranes at embryonic days E12, E15, and E18. Bgn(-/-)Dcn(-/-) dams displayed preterm birth, whereas the possession of at least two biglycan or decorin wild-type alleles was protective of preterm birth. The number of Bgn(-/-)Dcn(-/-) pups was decreased at postnatal day P1 but not at E18. Biglycan and decorin were upregulated in the placenta in the absence of each other and were developmentally regulated in fetal membranes, suggesting that these two proteoglycans demonstrate genetic complementation and contribute to gestational success in a dose-dependent manner. Thus, the biglycan/decorin null mutant mouse is a model of genetically induced preterm birth and perinatal loss. This model presents novel targets for preventive or therapeutic manipulation of preterm birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.