ArticleThe Journal of physiology2011
Dorsal-ventral organization of theta-like activity intrinsic to entorhinal stellate neurons is mediated by differences in stochastic current fluctuations.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
- Heterogeneous stochastic bifurcations explain intrinsic oscillatory patterns in entorhinal cortical stellate cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Spiking Neural Networks and Hippocampal Function: A Web-Accessible Survey of Simulations, Modeling Methods, and Underlying Theories.Cognitive systems research · 2021Article
- Article
- Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells.Journal of theoretical biology · 2018Article
- Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient.The Journal of physiology · 2018Article
- Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- A hybrid oscillatory interference/continuous attractor network model of grid cell firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- How to build a grid cell.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Theta rhythm and the encoding and retrieval of space and time.NeuroImage · 2014Review
- How does the modular organization of entorhinal grid cells develop?Frontiers in human neuroscience · 2014Article
- Nonlinear properties of medial entorhinal cortex neurons reveal frequency selectivity during multi-sinusoidal stimulation.Frontiers in cellular neuroscience · 2014Article
- Cellular mechanisms of spatial navigation in the medial entorhinal cortex.Nature neuroscience · 2013Article
- Article
- Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.Journal of neurophysiology · 2013Article
- Voltage dependence of subthreshold resonance frequency in layer II of medial entorhinal cortex.Hippocampus · 2012Article
- Preparation of parasagittal slices for the investigation of dorsal-ventral organization of the rodent medial entorhinal cortex.Journal of visualized experiments : JoVE · 2012Article
- How entorhinal grid cells may learn multiple spatial scales from a dorsoventral gradient of cell response rates in a self-organizing map.PLoS computational biology · 2012Article
- Intrinsic electrophysiological properties of entorhinal cortex stellate cells and their contribution to grid cell firing fields.Frontiers in neural circuits · 2012Article
- Models of grid cell spatial firing published 2005-2011.Frontiers in neural circuits · 2012Article
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3 authors.
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Abstract
The membrane potential dynamics of stellate neurons in layer II of the medial entorhinal cortex are important for neural encoding of location. Previous studies suggest that these neurons generate intrinsic theta-frequency membrane potential oscillations, with a period that depends on neuronal location on the dorsal–ventral axis of themedial entorhinal cortex, and which in behaving animals could support generation of grid-like spatial firing fields. To address the nature and organization of this theta-like activity, we adopt the Lombmethod of least-squares spectral analysis. We demonstrate that peaks in frequency spectra that differ significantly from Gaussian noise do not necessarily imply the existence of a periodic oscillator, but can instead arise from filtered stochastic noise or a stochastic random walk. We show that theta-like membrane potential activity recorded fromstellate neurons in mature brain slices is consistentwith stochastic mechanisms, but not with generation by a periodic oscillator. The dorsal–ventral organization of intrinsic theta-likemembrane potential activity, and themodification of this activity during block of HCN channels, both reflect altered frequency distributions of stochastic spectral peaks, rather than tuning of a periodic oscillator. Our results demonstrate the importance of distinguishing periodic oscillations from stochastic processes.We suggest that dorsal–ventral tuning of theta-like membrane potential activity is due to differences in stochastic current fluctuations resulting from organization of ion channels that also control synaptic integration.
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