ArticleDrug and alcohol dependence2011
Use of item response theory and latent class analysis to link poly-substance use disorders with addiction severity, HIV risk, and quality of life among opioid-dependent patients in the Clinical Trials Network.
Article in Drug and alcohol dependence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- An item response theory based integrated model of headache, nausea, photophobia, and phonophobia in migraine patients.Journal of pharmacokinetics and pharmacodynamics · 2018Trial
- Alcohol use disorders are associated with increased HIV risk behaviors in cocaine-dependent methadone patients.Journal of substance abuse treatment · 2017Trial
- Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.General hospital psychiatryTrial
- Polysubstance Use and Related Risk Behaviors among People Who Inject Drugs in Kenya Preparing for Hepatitis C Virus Treatment.Viruses · 2024Article
- Patient feasibility as a novel approach for integrating IRT and LCA statistical models into patient-centric qualitative data-a pilot study.Frontiers in digital health · 2024Article
- Influence of polysubstance use on the health-related quality of life among people who inject drugs undergoing opioid agonist treatment following treatment for hepatitis c virus.Journal of substance use · 2024Article
- Problematic Gambling Behavior in a Sample with Substance Use Disorder: The Role of Attachment Style and Alexithymia.Journal of gambling studies · 2023Article
- Patterns of polysubstance use and clinical comorbidity among persons seeking substance use treatment: An observational study.Journal of substance use and addiction treatment · 2023Observational
- Adolescent substance use and high school noncompletion: exploring the nature of the relationship using a discordant twin design.Addiction (Abingdon, England) · 2023Article
- Latent Classes of Polysubstance Use and Associations with HIV Risk and Structural Vulnerabilities among Cisgender Women Who Engage in Street-Based Transactional Sex in Baltimore City.International journal of environmental research and public health · 2022Article
- Profiles of lifetime substance use are differentiated by substance of choice, affective motivations for use, and childhood maltreatment.Addictive behaviors · 2021Article
- The Relationship Between Polysubstance Injection Drug Use, HIV Risk Behaviors, and Interest in Pre-Exposure Prophylaxis (PrEP) Among People Who Inject Drugs in Rural West Virginia.Journal of studies on alcohol and drugs · 2020Article
- Characterizing profiles of polysubstance use among high school students in Baltimore, Maryland: A latent class analysis.Drug and alcohol dependence · 2020Article
- Adolescent Anabolic-Androgenic Steroid Use in Association with Other Drug Use, Injection Drug Use, and Team Sport Participation.Journal of child & adolescent substance abuse · 2020Article
- Utilizing social media to explore overdose and HIV/HCV risk behaviors among current opioid misusers.Drug and alcohol dependence · 2019Article
- A latent class approach to identify multi-risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015.Journal of the International AIDS Society · 2019Article
- Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco.Drug and alcohol dependence · 2019Article
- Prevalence, patterns, and correlates of multiple substance use disorders among adult primary care patients.Drug and alcohol dependence · 2018Article
- Using item response theory with health system data to identify latent groups of patients with multiple health conditions.PloS one · 2018Article
- Latent classes of polydrug and polyroute use and associations with human immunodeficiency virus risk behaviours and overdose among people who inject drugs in Tijuana, Baja California, Mexico.Drug and alcohol review · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundThis study applied item response theory (IRT) and latent class analysis (LCA) procedures to examine the dimensionality and heterogeneity of comorbid substance use disorders (SUDs) and explored their utility for standard clinical assessments, including the Addiction Severity Index (ASI), HIV Risk Behavior Scale (HRBS), and SF-36 quality-of-life measures.
methodsThe sample included 343 opioid-dependent patients enrolled in two national multisite studies of the U.S. National Drug Abuse Treatment Clinical Trials Network (CTN001-002). Patients were recruited from inpatient and outpatient addiction treatment settings at 12 programs. Data were analyzed by factor analysis, IRT, LCA, and latent regression procedures.
resultsA two-class LCA model fit dichotomous SUD data empirically better than one-parameter and two-parameter IRT models. LCA distinguished 10% of severe comorbid opioid-dependent individuals who had high rates of all SUDs examined-especially amphetamine and sedative abuse/dependence-from the remaining 90% who had SUDs other than amphetamine and sedative abuse/dependence (entropy=0.99). Item-level results from both one-parameter and two-parameter IRT models also found that amphetamine and sedative abuse/dependence tapped the more severe end of the latent poly-SUD trait. Regardless of whether SUDs were defined as a continuous trait or categorically, individuals characterized by a high level of poly-SUD demonstrated more psychiatric problems and HIV risk behaviors.
conclusionsA combined application of categorical and dimensional latent approaches may improve the understanding of comorbid SUDs and their associations with other clinical indicators. Abuse of sedatives and methamphetamine may serve as a useful marker for identifying subsets of opioid-dependent individuals with needs for more intensive interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.