ArticleToxicology letters2012
Adductomics: characterizing exposures to reactive electrophiles.
Article in Toxicology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
83 citing papers in PubMed, 181 citations in OpenAlex.
- Cord Blood Adductomic Profiling Provides Preliminary Insights on Perinatal Smoking Exposure: A Pilot Analysis.Antioxidants (Basel, Switzerland) · 2026Article
- Generation and characterization of a serum albumin-humanized mouse model and its utility for detection of albumin adduct formation in vivo.Drug metabolism and disposition: the biological fate of chemicals · 2026Article
- Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi.Chemical research in toxicology · 2025Article
- Mapping assays to the key characteristics of carcinogens to support decision-making.Database : the journal of biological databases and curation · 2025Article
- The need for a cancer exposome atlas: a scoping review.JNCI cancer spectrum · 2025Article
- Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization.Trends in analytical chemistry : TRAC · 2024Article
- Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia.Antioxidants (Basel, Switzerland) · 2024Article
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- The contribution of the exposome to the burden of cardiovascular disease.Nature reviews. Cardiology · 2023Review
- A nested case-control study of untargeted albumin adductomics and acute myeloid leukemia.International journal of cancer · 2023Article
- Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers.Journal of clinical medicine · 2023Review
- Pathways to Identify ElectrophilesChemical research in toxicology · 2022Article
- Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin.Environmental toxicology and pharmacology · 2022Article
- Discovery and Visualization of Uncharacterized Drug-Protein Adducts Using Mass Spectrometry.Analytical chemistry · 2022Article
- Detection of Benzo[Toxics · 2022Article
- The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.Environmental toxicology and chemistry · 2022Article
- Haptenation of Macrophage Migration Inhibitory Factor: A Potential Biomarker for Contact Hypersensitivity.Frontiers in toxicology · 2022Article
- Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.Environmental science & technology letters · 2021Review
- Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research.International journal of molecular sciences · 2021Review
- Protein Adducts and Protein Oxidation as Molecular Mechanisms of Flavonoid Bioactivity.Molecules (Basel, Switzerland) · 2021Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most important constituents of the exposome. Exposures to reactive electrophiles can be characterized by measuring adducts from reactions between circulating electrophiles and blood nucleophiles. We define an 'adductome' as the totality of such adducts with a given nucleophilic target. Because of their greater abundance and residence times in human blood, adducts of hemoglobin (Hb) and human serum albumin (HSA) are preferable to those of DNA and glutathione for characterizing adductomes. In fact, the nucleophilic hotspot represented by the only free sulfhydryl group in HSA (HSA-Cys(34)) offers particular advantages for adductomic experiments. Although targeted adducts of HSA-Cys(34) have been monitored for decades, an unbiased method has only recently been reported for visualizing the HSA-Cys(34) 'subadductome'. The method relies upon a novel mass spectrometry application, termed fixed-step selected reaction monitoring (FS-SRM), to profile Cys(34) adducts in tryptic digests of HSA. Here, we selectively review the literature regarding the potential of adductomics to partially elucidate the human exposome, with particular attention to the HSA-Cys(34) subadductome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.