ArticleBiochemical pharmacology2011
Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation.
Article in Biochemical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Development of 9-(3 Biotech · 2023Article
- Noscapine-Amino Acid Conjugates Suppress the Progression of Cancer Cells.ACS pharmacology & translational science · 2022Article
- Biofabrication of ecofriendly copper oxide nanoparticles using Ocimum americanum aqueous leaf extract: analysis of in vitro antibacterial, anticancer, and photocatalytic activities.Environmental science and pollution research international · 2021Article
- Bioengineering of Anti-Inflammatory Natural Products.ChemMedChem · 2021Review
- Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents.Scientific reports · 2019Article
- Imidazo[2,1-ACS omega · 2019Article
- A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation.Oncotarget · 2016Article
- Metabolism profiling of amino-noscapine.European journal of drug metabolism and pharmacokinetics · 2016Article
- Metabolic pathway profiling of the derivative of important herbal component noscapine.European journal of drug metabolism and pharmacokinetics · 2016Article
- The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.Medicinal research reviews · 2015Review
- Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents.Bioorganic & medicinal chemistry letters · 2015Article
- Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity.Biochemical pharmacology · 2014Article
- Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.European journal of medicinal chemistry · 2014Article
- Article
- Peloruside, laulimalide, and noscapine interactions with beta-tubulin.Pharmaceutical research · 2012Review
- Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.Cell death & disease · 2012Article
- Molecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cells.Molecular pharmaceutics · 2012Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Microtubules, composed of α/β tubulin heterodimers, represent a validated target for cancer chemotherapy. Thus, tubulin- and microtubule-binding antimitotic drugs such as taxanes and vincas are widely employed for the chemotherapeutic management of various malignancies. Although quite successful in the clinic, these drugs are associated with severe toxicity and drug resistance problems. Noscapinoids represent an emerging class of microtubule-modulating anticancer agents based upon the parent molecule noscapine, a naturally occurring non-toxic cough-suppressant opium alkaloid. Here we report in silico molecular modeling, chemical synthesis and biological evaluation of novel analogs derived by modification at position-7 of the benzofuranone ring system of noscapine. The synthesized analogs were evaluated for their tubulin polymerization activity and their biological activity was examined by their antiproliferative potential using representative cancer cell lines from varying tissue-origin [A549 (lung), CEM (lymphoma), MIA PaCa-2 (pancreatic), MCF-7 (breast) and PC-3 (prostate)]. Cell-cycle studies were performed to explore their ability to halt the cell-cycle and induce subsequent apoptosis. The varying biological activity of these analogs that differ in the nature and bulk of substituent at position-7 was rationalized utilizing predictive in silico molecular modeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.