ArticleBMC gastroenterology2011
Transient elastography for predicting esophageal/gastric varices in children with biliary atresia.
Article in BMC gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis.World journal of gastroenterology · 2022Pooled it
- Biomarkers for the diagnosis and post-Kasai portoenterostomy prognosis of biliary atresia: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Diagnostic Accuracy of Liver Stiffness Measurement as a Non-Invasive Tool for Variceal Screening in Pediatric Chronic Liver Disease: A Systematic Review and Meta-Analysis.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Evaluation of Hepatic Shear Wave Elastography to Assess Liver Fibrosis in Biliary Atresia Patients and Its Correlation with Liver Histology and Surgical Outcomes: A Prospective Observational Study.The Indian journal of radiology & imaging · 2024Article
- Preoperative imaging findings to predict 2-year native liver survival after the Kasai procedure in patients with biliary atresia.European radiology · 2024Article
- Budd-Chiari syndrome in children: Challenges and outcome.World journal of hepatology · 2023Review
- Treatment of Cholestasis in Infants and Young Children.Current gastroenterology reports · 2023Review
- Shear wave elastography of the spleen using elastography point quantification: stiffness values in healthy children.Abdominal radiology (New York) · 2022Article
- A Nomogram Predicting the Prognosis of Children With Biliary Atresia After Hepatoportoenterostomy.Frontiers in pediatrics · 2021Article
- Splenic stiffness and platelet count to predict varices needing treatment in pediatric extrahepatic portal vein obstruction.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease.Hepatology communications · 2020Article
- Hepatic subcapsular or capsular flow in biliary atresia: is it useful imaging feature after the Kasai operation?European radiology · 2020Article
- Spleen stiffness measurement as a non-invasive test to evaluate and monitor portal hypertension in children with extrahepatic portal vein obstruction.Pediatric surgery international · 2020Article
- Feasibility study and reference values of FibroScan 502 with M probe in healthy preschool children aged 5 years.BMC pediatrics · 2019Article
- Noninvasive Evaluation of Liver Fibrosis and Portal Hypertension After Successful Portoenterostomy for Biliary Atresia.Hepatology communications · 2019Article
- Predicting gastroesophageal varices through spleen magnetic resonance elastography in pediatric liver fibrosis.World journal of gastroenterology · 2019Article
- Advances in diagnosis of chronic liver diseases in pediatric patients.World journal of pediatrics : WJP · 2018Review
- Transient Elastography for Detection of Liver Fibrosis in Children With Autosomal Recessive Polycystic Kidney Disease.Frontiers in pediatrics · 2018Article
- Liver stiffness measurements with supersonic shear wave elastography in the diagnosis of biliary atresia: a comparative study with grey-scale US.European radiology · 2017Article
- Biomarkers and imaging studies to predict portal hypertension and varices.Clinical liver disease · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient elastography (TE) is an innovative, noninvasive technique to assess liver fibrosis by measuring liver stiffness in patients with chronic liver diseases. The purpose of this study has been to explore the accuracy of TE and clinical parameters in predicting the presence of esophageal/gastric varices in children with biliary atresia (BA) following portoenterostomy.
methodsPatients with BA status post portoenterostomy and normal children were recruited. Splenomegaly and presence of EV/GV were determined by physical examination and endoscopy, respectively. Aspartate transaminase to platelet ratio index (APRI) was used as a serum fibrosis marker. TE was performed by using FibroScan. Data was expressed as mean ± SD.
resultsSeventy-three BA patients (male:female = 32:41; age 9.11 ± 5.64 years) and 50 normal controls (male:female = 19:31; age 11.00 ± 3.31 years) were enrolled. The liver stiffness score of BA patients was significantly higher than that of normal controls (27.37 ± 22.48 and 4.69 ± 1.03 kPa; p < 0.001). Patients with EV/GV had significantly higher liver stiffness score and APRI than those without EV/GV. As for EV/GV diagnosis, the areas under the receiver operating characteristic curve were 0.89 (95% CI 0.80 to 0.98) for TE and 0.87 (95% CI 0.78 to 0.96) for APRI, respectively. The sensitivity (and specificity) of TE (using a cut-off value of 12.7 kPa) and APRI (using a cut-off value of 1.92) in predicting EV/GV were 84% (77%) and 84% (83%), respectively, whereas the sensitivity (and specificity) of splenomegaly in predicting EV/GV were 92% (85%).
conclusionsTransient elastography is a useful tool for predicting the presence of EV/GV. In addition, basic physical examination, routine biochemical and hematological tests, are still worthwhile and correlate well with the presence of EV/GV in patients with BA post portoenterostomy.
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