ArticleBritish journal of clinical pharmacology2011
Road traffic accidents and psychotropic medication use in The Netherlands: a case-control study.
Article in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Residual effects of zopiclone on driving performance using a standardized driving simulator among healthy volunteers.Psychopharmacology · 2022Trial
- Fine particulate matter exposure and risk of scooter collisions among older adults.Injury epidemiology · 2025Article
- Nonbenzodiazepine hypnotics and police-reported motor vehicle crash risk among older adults: a sequential target trial emulation.American journal of epidemiology · 2025Article
- Effectiveness of road safety interventions: An evidence and gap map.Campbell systematic reviews · 2024Article
- Article
- Trends in the Use of Driving-Impairing Medicines According to the DRUID Category: A Population-Based Registry Study with Reference to Driving in a Region of Spain between 2015 and 2019.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Use of psychotropic medication and risk of road traffic crashes: a registry-based case-control study in Denmark, 1996-2018.Psychopharmacology · 2022Article
- Neuropsychological exponents for the driving ability in remitted bipolar patients.International journal of bipolar disorders · 2022Article
- A Nationwide Population-Based Study on the Association between Land Transport Accident and Peripheral Vestibular Disorders.International journal of environmental research and public health · 2021Article
- Trends in Antidepressants Use in Spain between 2015 and 2018: Analyses from a Population-Based Registry Study with Reference to Driving.Pharmaceuticals (Basel, Switzerland) · 2020Article
- The association between antidepressant use and deaths from road traffic accidents: a case-crossover study.Social psychiatry and psychiatric epidemiology · 2019Article
- Trends in benzodiazepine anxiolytics and z-hypnotics use among French drivers involved in road traffic crashes from 2005 to 2015: a responsibility case-control study.Injury epidemiology · 2019Article
- Prevalence of consumption of psychoactive substances amongst Moroccan taxi drivers.La Medicina del lavoro · 2018Observational
- Impact of Medical Conditions and Medications on Road Traffic Safety.Oman medical journal · 2018Article
- Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database.BMC medicine · 2018Article
- Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.Journal of Alzheimer's disease : JAD · 2018Article
- Depression, antidepressants and driving safety.Injury epidemiology · 2017Review
- Use of driving-impairing medicines by a Spanish population: a population-based registry study.BMJ open · 2017Article
- Road traffic crash risk associated with benzodiazepine and z-hypnotic use after implementation of a colour-graded pictogram: a responsibility study.British journal of clinical pharmacology · 2016Article
- Patients reasons for obtaining psychotropic medications without a prescription at retail pharmacies in Central Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2016Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the association between the use of commonly prescribed psychotropic medications and road traffic accident risk.
methodsA record-linkage database was used to perform a case-control study in The Netherlands. The data came from three sources: pharmacy prescription data, police traffic accident data and driving licence data. Cases were defined as drivers, who had a traffic accident that required medical assistance between 2000 and 2007. Controls were defined as adults, who had a driving licence and had no traffic accident during the study period. Four controls were matched for each case. The following psychotropic medicine groups were examined: antipsychotics, anxiolytics, hypnotics and sedatives, and antidepressants stratified in the two groups, SSRIs and other antidepressants. Various variables, such as age, gender, medicine half-life and alcohol use, were considered for the analysis.
resultsThree thousand nine hundred and sixty-three cases and 18,828 controls were included in the case-control analysis. A significant association was found between traffic accident risk and exposure to anxiolytics (OR = 1.54, 95% CI 1.11, 2.15), and SSRIs (OR = 2.03, 95% CI 1.31, 3.14). A statistically significant increased risk was also seen in chronic anxiolytic users, females and young users (18 to 29 years old), chronic SSRI users, females and middle-aged users (30 to 59 years old), and intermediate half-life hypnotic users.
conclusionsThe results of this study support previous findings and confirm that psychoactive medications can constitute a problem in traffic safety. Both health care providers and patients should be properly informed of the potential risks associated with the use of these medicines.
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