ArticleJournal of clinical periodontology2011
Gingival tissue transcriptomes in experimental gingivitis.
Article in Journal of clinical periodontology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Trial
- Vitamin D deficiency in mice modulates oral microbiome stability over time and leads to changes in host inflammatory gene expression pathways.Frontiers in cellular and infection microbiology · 2026Article
- Systematic Review of Experimental Gingivitis Induction Methods: Methodological Variations and Their Impact on Inflammation Progression.Patient preference and adherence · 2025Review
- Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis.International dental journal · 2023Article
- Association of rs142548867 (EEFSEC) and periodontitis Grade C in a young Brazilian population.Journal of applied oral science : revista FOB · 2023Article
- MicroRNAs: Harbingers and shapers of periodontal inflammation.Seminars in cell & developmental biology · 2022Review
- Gingival Displacement in the Vertical and Horizontal Dimension under the Condition of Mild Gingivitis-A Randomized Clinical Study.Journal of clinical medicine · 2022Article
- Microbiota in Periodontitis: Advances in the Omic Era.Advances in experimental medicine and biology · 2022Review
- Influence of the Gingival Condition on the Performance of Different Gingival Displacement Methods-A Randomized Clinical Study.Journal of clinical medicine · 2021Article
- Transcriptomic phases of periodontitis lesions using the nonhuman primate model.Scientific reports · 2021Article
- Reliability of microarray analysis for studying periodontitis: low consistency in 2 periodontitis cohort data sets from different platforms and an integrative meta-analysis.Journal of periodontal & implant science · 2021Article
- Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and RegulatedFrontiers in immunology · 2021Article
- Salivary proteotypes of gingivitis tolerance and resilience.Journal of clinical periodontology · 2020Article
- Transcriptomic profiles and their correlations in saliva and gingival tissue biopsy samples from periodontitis and healthy patients.Journal of periodontal & implant science · 2020Article
- An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases.International journal of molecular sciences · 2020Review
- Periodontal inflammation: Integrating genes and dysbiosis.Periodontology 2000 · 2020Review
- The Human Salivary Antimicrobial Peptide Profile according to the Oral Microbiota in Health, Periodontitis and Smoking.Journal of innate immunity · 2019Article
- Age and Periodontal Health - Immunological View.Current oral health reports · 2018Article
- Differential Expression and Functional Analysis of High-Throughput -Omics Data Using Open Source Tools.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Genome-Wide Analysis of Periodontal and Peri-Implant Cells and Tissues.Methods in molecular biology (Clifton, N.J.) · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsWe investigated the sequential gene expression in the gingiva during the induction and resolution of experimental gingivitis. MATERIAL AND
methodsTwenty periodontally and systemically healthy non-smoking volunteers participated in a 3-week experimental gingivitis protocol, followed by debridement and 2-week regular plaque control. We recorded clinical indices and harvested gingival tissue samples from four interproximal palatal sites in half of the participants at baseline, Day 7, Day 14 and Day 21 (the "induction phase"), and at Day 21, Day 25, Day 30 and Day 35 in the other half (the "resolution phase"). RNA was extracted, amplified, reversed transcribed, amplified, labelled and hybridized using Affymetrix Human Genome U133Plus2.0 microarrays. Paired t-tests compared gene expression changes between consecutive time points. Gene ontology analyses summarized the expression patterns into biologically relevant categories.
resultsThe median gingival index was 0 at baseline, 2 at Day 21 and 1 at Day 35. Differential gene regulation peaked during the third week of induction and the first 4 days of resolution. Leucocyte transmigration, cell adhesion and antigen processing/presentation were the top differentially regulated pathways.
conclusionsTranscriptomic studies enhance our understanding of the pathobiology of the reversible inflammatory gingival lesion and provide a detailed account of the dynamic tissue responses during the induction and resolution of experimental gingivitis.
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Registered trials
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