ArticleBehavioral neuroscience2011
Proinflammatory activity and the sensitization of depressive-like behavior during maternal separation.
Article in Behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Salivary cortisol measurements in brachycephalic dog breeds as part of a standardized stress test.Frontiers in veterinary science · 2024Article
- Examination of the role of adrenergic receptor stimulation in the sensitization of neuroinflammatory-based depressive-like behavior in isolated Guinea pig pups.Stress (Amsterdam, Netherlands) · 2023Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
- Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model.Frontiers in pharmacology · 2020Article
- Cold parenting is associated with cellular aging in offspring: A retrospective study.Biological psychology · 2019Article
- Effects of early life stress on cocaine conditioning and AMPA receptor composition are sex-specific and driven by TNF.Brain, behavior, and immunity · 2019Article
- Central neuroimmune activity and depressive-like behavior in response to repeated maternal separation and injection of LPS.Physiology & behavior · 2019Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Blood‒Brain Barrier Pathology and CNS Outcomes inInternational journal of molecular sciences · 2018Review
- Anhedonic behavior and γ-amino butyric acid during a sensitive period in female rats exposed to early adversity.Journal of psychiatric research · 2018Article
- Early Attachment Disruption, Inflammation, and Vulnerability for Depression in Rodent and Primate Models.Frontiers in behavioral neuroscience · 2018Article
- Maternal separation increases later immobility during forced swim in guinea pig pups: evidence for sensitization of a depressive-like state.Developmental psychobiology · 2017Article
- Formula Feeding Predisposes Gut to NSAID-Induced Small Intestinal Injury.Clinical & experimental pharmacology · 2016Article
- Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity.Developmental cognitive neuroscience · 2015Article
- Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation.Physiology & behavior · 2015Article
- Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease.Stress (Amsterdam, Netherlands) · 2015Review
- Filial attachment and its disruption: insights from the guinea pig.Developmental psychobiology · 2014Review
- Sociality and sickness: have cytokines evolved to serve social functions beyond times of pathogen exposure?Brain, behavior, and immunity · 2014Review
- The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications.Molecular psychiatry · 2013Review
- Persistent sensitization of depressive-like behavior and thermogenic response during maternal separation in pre- and post-weaning guinea pigs.Developmental psychobiology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
When guinea pig pups are isolated for a few hours in a novel environment, they exhibit a distinctive passive behavioral response that appears to be mediated by proinflammatory activity. Recently, we observed that pups separated on two consecutive days show an enhanced (sensitized) passive response on the second day. In Experiment 1, pups receiving intracerebroventricular infusion of 50 ng of the anti-inflammatory cytokine interleukin-10 prior to a first separation failed to show a sensitized behavioral response to separation the next day. In Experiment 2, pups separated on Days 1 and 2, or just 2, showed an increase in passive responding during separation on Day 5. Pups injected with the bacterial antigen lipopolysacchride (LPS; 75 μg/kg body weight, intraperitoneal) prior to separation on Day 1 showed an increase in passive behavior several days later not shown by pups injected with saline prior to Day 1 separation. However, injection of LPS without separation on the first day did not enhance responding during an initial separation on the second day. These results suggest that immune activation is necessary, but not sufficient, to account for the sensitization of passive behavior of isolated guinea pig pups the following day, that boosting proinflammatory activity during an initial separation may promote sensitization several days later, and that the sensitized response persists for at least several days.
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