ArticleJournal of clinical and experimental neuropsychology2011
Dimensions of personality disturbance after focal brain damage: investigation with the Iowa Scales of Personality Change.
Article in Journal of clinical and experimental neuropsychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Combined frontal cavernoma and developmental venous angioma presenting as organic personality disorder: a case report.BMC psychiatry · 2025Article
- Longitudinal behavioral and neuropsychiatric changes and their MRI correlates in predementiaJournal of Alzheimer's disease : JAD · 2025Article
- Reduced mind-wandering and fewer depressive symptoms associated with damage to the medial prefrontal cortex and default mode network.Neuropsychologia · 2025Article
- A Patient-Centered Perspective on Changes in Personal Characteristics After Deep Brain Stimulation.JAMA network open · 2024Article
- Economic and social values in the brain: evidence from lesions to the human ventromedial prefrontal cortex.Frontiers in neurology · 2023Review
- Lesions in different prefrontal sectors are associated with different types of acquired personality disturbances.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Observational
- Forensic psychiatric analysis of organic personality disorders after craniocerebral injury in Shanghai, China.Frontiers in psychiatry · 2022Article
- Personality Changes After Subthalamic Nucleus Stimulation in Parkinson's Disease.Journal of Parkinson's disease · 2022Observational
- Assessing the Effects of Healthy and Neuropathological Aging on Personality with the Iowa Scales of Personality Change.Developmental neuropsychology · 2021Article
- Neural correlates of improvements in personality and behavior following a neurological event.Neuropsychologia · 2020Article
- Acquired Personality Disturbances After Meningioma Resection Are Strongly Associated With Impaired Quality of Life.Neurosurgery · 2020Article
- Personality and Cognitive Functions in Violent Offenders - Implications of Character Maturity?Frontiers in psychology · 2020Article
- What is the functional/organic distinction actually doing in psychiatry and neurology?Wellcome open research · 2020Review
- Soft on crime: Patients with ventromedial prefrontal cortex damage allocate reduced third-party punishment to violent criminals.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Pragmatism and the Importance of Interdisciplinary Teams in Investigating Personality Changes following DBS.Neuroethics · 2019Article
- "Frontal lobe syndrome"? Subtypes of acquired personality disturbances in patients with focal brain damage.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Comparing and Contrasting the Cognitive Effects of Hippocampal and Ventromedial Prefrontal Cortex Damage: A Review of Human Lesion Studies.Neuroscience · 2018Review
- Stable psychological functioning after surgery for epilepsy: An informant-based perspective.Epilepsy & behavior : E&B · 2017Article
- Hippocampal Damage Increases Deontological Responses during Moral Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- 'Just can't hide it': a behavioral and lesion study on emotional response modulation after right prefrontal damage.Social cognitive and affective neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
This study employed a multistep, rational-empirical approach to identify dimensions of personality disturbance in brain-damaged individuals: (a) Five dimensions were hypothesized based on empirical literature and conceptual grounds; (b) principal components analysis was performed on the Iowa Scales of Personality Change (ISPC) to determine the pattern of covariance among 30 personality characteristics; (c) when discrepancies existed between principal components analysis results and conceptually based dimensions, empirical findings and clinical considerations were weighed to determine assignment of ISPC scales to dimensions; (d) the fit of data to the refined dimensions was assessed by examination of intercorrelations; (e) differential predictions concerning the relationship of dimensions to ventromedial prefrontal cortex (vmPFC) damage were tested. This process resulted in the specification of five dimensions: Disturbed Social Behavior, Executive/Decision-Making Deficits, Diminished Motivation/Hypo-Emotionality, Irascibility, and Distress. In accord with predictions, the 28 participants with vmPFC lesions, compared to 96 participants with focal lesions elsewhere in the brain, had significantly more Disturbed Social Behavior and Executive/Decision-Making Deficits and tended to have more Diminished Motivation/Hypo-Emotionality. Irascibility was not significantly higher among the vmPFC group, and the groups had very similar levels of Distress. The findings indicate that conceptually distinctive dimensions with differential relationships to vmPFC can be derived from the Iowa Scales of Personality Change.
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