ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2011
Species-driven interpretation guidelines in case of a single-sampling strategy for blood culture.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05686577 (Comment Diminuer Les hémocultures Inutiles), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comment Diminuer Les hémocultures Inutiles : Construction et Validation d'un Score prédictif de positivité Des hémocultures en réanimation.
Who cites it
13 citing papers in PubMed.
- Diagnostic performance of a multiple real-time PCR assay in patients with suspected sepsis hospitalized in an internal medicine ward.Journal of clinical microbiology · 2012Trial
- Blood culture practices and microbiological capacity for sepsis diagnostics in Europe (2021-2022): a cross-sectional analysis of the European Sepsis Care Survey.The Lancet regional health. Europe · 2026Article
- Diagnostic value of blood culture growth patterns in distinguishing contaminants from pathogens.Journal of clinical microbiology · 2026Article
- Evaluation of a digital remote extraction analysis and monitoring tool for key performance indicators (KPIs) in the blood culture process.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Detection of relevant pathogens and contaminants in blood cultures after implementation of single-sampling strategy and initial specimen diversion.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- It is time for a unified definition of native vertebral osteomyelitis: a framework proposal.Journal of bone and joint infection · 2024Review
- Single-Site Sampling versus Multisite Sampling for Blood Cultures: a Retrospective Clinical Study.Journal of clinical microbiology · 2022Article
- Clinical Significance ofOpen forum infectious diseases · 2022Article
- Optimized blood culture strategy to document febrile neutropenia.Pediatric research · 2021Article
- Low prevalence of bloodstream infection and high blood culture contamination rates in patients with COVID-19.PloS one · 2020Article
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study.PloS one · 2019Article
- How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art.Frontiers in microbiology · 2016Review
- Clinical consequences of using PNA-FISH in Staphylococcal bacteraemia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this paper is to define guidelines to interpret positive blood cultures (BCs) to distinguish bloodstream infection (BSI) from contamination in BCs drawn with a single venipuncture. During a 2-year period, each positive BC set (comprising six bottles from a single venipuncture) was prospectively categorised by clinicians, bacteriologists and hospital epidemiologists as BSI or contamination. For each case, the number of positive bottles per set, results from Gram staining and microorganism identification were analysed in order to define interpretation guidelines. We analysed 940 positive BC sets. The BSI rate in monomicrobial BC sets was positively correlated with the number of positive bottles. The positive predictive value was 88% with one and 100% with ≥2 positive bottles for Escherichia coli; 100% for Staphylococcus aureus, Pseudomonas and Candida spp., regardless of the number of positive bottles; 3.5%, 61.1%, 78.9% and 100% for coagulase-negative staphylococci (CoNS) with one, two, three and ≥4 positive bottles, respectively. Using a single-sampling strategy, interpretation guidelines for monomicrobial positive BCs are based on the number of positive bottles per set, results from Gram staining and microorganism identification: ≥4 positive bottles (≥2 with Gram-negative bacilli) always led to a diagnosis of BSI. The CoNS BSI rate positively correlates with the number of positive bottles.
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Registered trials
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